eF-site ID 1f28-C PDB Code 1f28 Chain C click to enlarge Title CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89 Classification TRANSFERASE Compound THYMIDYLATE SYNTHASE Source Pneumocystis carinii (TYSY_PNECA) Sequence C:  NAEEQQYLNLVQYIINHGEDRPDRTGTGTLSVFAPSPLKF SLRNKTFPLLTTKRVFIRGVIEELLWFIRGETDSLKLREK NIHIWDANGSREYLDSIGLTKRQEGDLGPIYGFQWRHFGA EYIDCKTNYIGQGVDQLANIIQKIRTSPYDRRLILSAWNP ADLEKMALPPCHMFCQFYVHIPSNNHRPELSCQLYQRSCD MGLGVPFNIASYALLTCMIAHVCDLDPGDFIHVMGDCHIY KDHIEALQQQLTRSPRPFPTLSLNRSITDIEDFTLDDFNI QNYHPYETIKMKMSI Description (1)  THYMIDYLATE SYNTHASE (E.C. 2.1.1.45) FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89 Functional site 1) chain C residue 26 type sequence R description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 2) chain C residue 113 type sequence Y description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 3) chain C residue 170 type sequence L description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 4) chain C residue 173 type sequence C description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 5) chain C residue 174 type sequence H description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 6) chain C residue 198 type sequence Q description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 7) chain C residue 199 type sequence R description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 8) chain C residue 200 type sequence S description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 9) chain C residue 202 type sequence D description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 10) chain C residue 206 type sequence G description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 11) chain C residue 210 type sequence N description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 12) chain C residue 240 type sequence H description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 13) chain C residue 242 type sequence Y description BINDING SITE FOR RESIDUE UMP C 303 source : AC3 14) chain C residue 153 type sequence R description BINDING SITE FOR RESIDUE UMP D 304 source : AC4 15) chain C residue 154 type sequence R description BINDING SITE FOR RESIDUE UMP D 304 source : AC4 16) chain C residue 58 type sequence F description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 17) chain C residue 61 type sequence G description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 18) chain C residue 65 type sequence E description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 19) chain C residue 85 type sequence H description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 20) chain C residue 86 type sequence I description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 21) chain C residue 87 type sequence W description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 22) chain C residue 90 type sequence N description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 23) chain C residue 170 type sequence L description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 24) chain C residue 202 type sequence D description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 25) chain C residue 205 type sequence L description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 26) chain C residue 206 type sequence G description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 27) chain C residue 209 type sequence F description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 28) chain C residue 242 type sequence Y description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 29) chain C residue 296 type sequence S description BINDING SITE FOR RESIDUE F89 C 403 source : AC7 30) chain C residue 173 type ACT_SITE sequence C description Nucleophile => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI1 31) chain C residue 199 type BINDING sequence R description in other chain => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI2 32) chain C residue 210 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI2 33) chain C residue 240 type BINDING sequence H description in other chain => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI2 34) chain C residue 26 type BINDING sequence R description in other chain => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI2 35) chain C residue 153 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI3 36) chain C residue 202 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI3

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