eF-site ID 1f28-A PDB Code 1f28 Chain A click to enlarge Title CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89 Classification TRANSFERASE Compound THYMIDYLATE SYNTHASE Source Pneumocystis carinii (TYSY_PNECA) Sequence A:  NAEEQQYLNLVQYIINHGEDRPDRTGTGTLSVFAPSPLKF SLRNKTFPLLTTKRVFIRGVIEELLWFIRGETDSLKLREK NIHIWDANGSREYLDSIGLTKRQEGDLGPIYGFQWRHFGA EYIDCKTNYIGQGVDQLANIIQKIRTSPYDRRLILSAWNP ADLEKMALPPCHMFCQFYVHIPSNNHRPELSCQLYQRSCD MGLGVPFNIASYALLTCMIAHVCDLDPGDFIHVMGDCHIY KDHIEALQQQLTRSPRPFPTLSLNRSITDIEDFTLDDFNI QNYHPYETIKMKMSI Description (1)  THYMIDYLATE SYNTHASE (E.C. 2.1.1.45) FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89 Functional site 1) chain A residue 26 type sequence R description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 2) chain A residue 170 type sequence L description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 3) chain A residue 173 type sequence C description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 4) chain A residue 174 type sequence H description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 5) chain A residue 198 type sequence Q description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 6) chain A residue 199 type sequence R description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 7) chain A residue 200 type sequence S description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 8) chain A residue 202 type sequence D description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 9) chain A residue 206 type sequence G description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 10) chain A residue 210 type sequence N description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 11) chain A residue 240 type sequence H description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 12) chain A residue 242 type sequence Y description BINDING SITE FOR RESIDUE UMP A 301 source : AC1 13) chain A residue 153 type sequence R description BINDING SITE FOR RESIDUE UMP B 302 source : AC2 14) chain A residue 154 type sequence R description BINDING SITE FOR RESIDUE UMP B 302 source : AC2 15) chain A residue 58 type sequence F description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 16) chain A residue 61 type sequence G description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 17) chain A residue 65 type sequence E description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 18) chain A residue 85 type sequence H description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 19) chain A residue 86 type sequence I description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 20) chain A residue 87 type sequence W description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 21) chain A residue 90 type sequence N description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 22) chain A residue 170 type sequence L description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 23) chain A residue 202 type sequence D description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 24) chain A residue 205 type sequence L description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 25) chain A residue 206 type sequence G description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 26) chain A residue 209 type sequence F description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 27) chain A residue 296 type sequence S description BINDING SITE FOR RESIDUE F89 A 401 source : AC5 28) chain A residue 173 type ACT_SITE sequence C description Nucleophile => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 26 type BINDING sequence R description in other chain => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 199 type BINDING sequence R description in other chain => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 210 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 240 type BINDING sequence H description in other chain => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 153 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI3 34) chain A residue 202 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P0A884 source Swiss-Prot : SWS_FT_FI3 35) chain A residue 153-181 type prosite sequence RRLILSAWNPADLEKMALPPCHMFCQFYV description THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrlIlsaWNpadlekma.....LpPCHmfcQFyV source prosite : PS00091

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