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eF-site ID
|
1f0j-B |
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PDB Code
|
1f0j |
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Chain
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B |
|
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Title
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B |
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Classification
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HYDROLASE |
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Compound
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PHOSPHODIESTERASE 4B |
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Source
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Homo sapiens (Human) (PDE4B_HUMAN) |
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Sequence
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B: |
SISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRP
LTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV
AYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAA
AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG
FKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHM
SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA
DLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPM
CDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD
TLEDNRNWYQSMIPQAP
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Description
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Functional site
|
|
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1)
|
chain |
B |
| residue |
238 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN B 1201
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| source |
: AC3
|
|
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2)
|
chain |
B |
| residue |
274 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN B 1201
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| source |
: AC3
|
|
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3)
|
chain |
B |
| residue |
275 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE ZN B 1201
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| source |
: AC3
|
|
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4)
|
chain |
B |
| residue |
392 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE ZN B 1201
|
| source |
: AC3
|
|
|
5)
|
chain |
B |
| residue |
275 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MG B 1202
|
| source |
: AC4
|
|
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6)
|
chain |
B |
| residue |
234 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ARS B 1203
|
| source |
: AC7
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|
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7)
|
chain |
B |
| residue |
194 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ARS B 1211
|
| source |
: AC8
|
|
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8)
|
chain |
B |
| residue |
234 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Proton donor => ECO:0000305|PubMed:15003452, ECO:0007744|PDB:1ROR
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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9)
|
chain |
B |
| residue |
234 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
| source |
Swiss-Prot : SWS_FT_FI2
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10)
|
chain |
B |
| residue |
443 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
| source |
Swiss-Prot : SWS_FT_FI2
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|
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11)
|
chain |
B |
| residue |
238 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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12)
|
chain |
B |
| residue |
274 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
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13)
|
chain |
B |
| residue |
275 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0007744|PDB:1ROR
|
| source |
Swiss-Prot : SWS_FT_FI5
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|
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14)
|
chain |
B |
| residue |
392 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:3D3P
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
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15)
|
chain |
B |
| residue |
446 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000305|PubMed:15003452, ECO:0000305|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
| source |
Swiss-Prot : SWS_FT_FI7
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16)
|
chain |
B |
| residue |
487 |
| type |
MOD_RES |
| sequence |
A
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P14646
|
| source |
Swiss-Prot : SWS_FT_FI8
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