|
eF-site ID
|
1f0j-B |
PDB Code
|
1f0j |
Chain
|
B |
|
click to enlarge
|
|
Title
|
CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B |
Classification
|
HYDROLASE |
Compound
|
PHOSPHODIESTERASE 4B |
Source
|
Homo sapiens (Human) (PDE4B_HUMAN) |
|
Sequence
|
B: |
SISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRP
LTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV
AYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAA
AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG
FKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHM
SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA
DLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPM
CDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD
TLEDNRNWYQSMIPQAP
|
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Description
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
238 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN B 1201
|
source |
: AC3
|
|
2)
|
chain |
B |
residue |
274 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN B 1201
|
source |
: AC3
|
|
3)
|
chain |
B |
residue |
275 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE ZN B 1201
|
source |
: AC3
|
|
4)
|
chain |
B |
residue |
392 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE ZN B 1201
|
source |
: AC3
|
|
5)
|
chain |
B |
residue |
275 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE MG B 1202
|
source |
: AC4
|
|
6)
|
chain |
B |
residue |
234 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ARS B 1203
|
source |
: AC7
|
|
7)
|
chain |
B |
residue |
194 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ARS B 1211
|
source |
: AC8
|
|
8)
|
chain |
B |
residue |
234 |
type |
ACT_SITE |
sequence |
H
|
description |
Proton donor => ECO:0000305|PubMed:15003452, ECO:0007744|PDB:1ROR
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
9)
|
chain |
B |
residue |
234 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
10)
|
chain |
B |
residue |
443 |
type |
BINDING |
sequence |
Q
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
11)
|
chain |
B |
residue |
238 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
12)
|
chain |
B |
residue |
274 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
13)
|
chain |
B |
residue |
275 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:15003452, ECO:0007744|PDB:1ROR
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
14)
|
chain |
B |
residue |
392 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:3D3P
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
15)
|
chain |
B |
residue |
446 |
type |
BINDING |
sequence |
F
|
description |
BINDING => ECO:0000305|PubMed:15003452, ECO:0000305|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
|
source |
Swiss-Prot : SWS_FT_FI7
|
|
16)
|
chain |
B |
residue |
487 |
type |
MOD_RES |
sequence |
A
|
description |
Phosphoserine => ECO:0000250|UniProtKB:P14646
|
source |
Swiss-Prot : SWS_FT_FI8
|
|
|
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