eF-site ID 1ez0-ABCD PDB Code 1ez0 Chain A, B, C, D click to enlarge Title CRYSTAL STRUCTURE OF THE NADP+ DEPENDENT ALDEHYDE DEHYDROGENASE FROM VIBRIO HARVEYI. Classification OXIDOREDUCTASE Compound ALDEHYDE DEHYDROGENASE Source Vibrio harveyi (Beneckea harveyi) (ALDH_VIBHA) Sequence A:  TDNVFYATNAFTGEALPLAFPVHTEVEVNQAATAAAKVAR DFRRLNNSKRASLLRTIASELEARSDDIIARAHLETALPE VRLTGEIARTANQLRLFADVVNSGSYHQAILDTPNPTRAP LPKPDIRRQQIALGPVAVFGASNFPLAFSAAGGDTASALA AGCPVIVKGHTAHPGTSQIVAECIEQALKQEQLPQAIFTL LQGNQRALGQALVSHPEIKAVGFTGSVGGGRALFNLAHER PEPIPFYGELGAINPTFIFPSAMRAKADLADQFVASMTMG CGQFCTKPGVVFALNTPETQAFIETAQSLIRQQSPSTLLT PGIRDSYQSQVVSRGSDDGIDVTFSQAESPCVASALFVTS SENWRKHPAWEEEIFGPQSLIVVCENVADMLSLSEMLAGS LTATIHATEEDYPQVSQLIPRLEEIAGRLVFNGWPTGVEV GYAMVHGGPYPASTHSASTSVGAEAIHRWLRPVAYQALPE SLLPDSLKAENPLEIARAVDGKAA B:  NVFYATNAFTGEALPLAFPVHTEVEVNQAATAAAKVARDF RRLNNSKRASLLRTIASELEARSDDIIARAHLETALPEVR LTGEIARTANQLRLFADVVNSGSYHQAILDTPNPTRAPLP KPDIRRQQIALGPVAVFGASNFPLAFSAAGGDTASALAAG CPVIVKGHTAHPGTSQIVAECIEQALKQEQLPQAIFTLLQ GNQRALGQALVSHPEIKAVGFTGSVGGGRALFNLAHERPE PIPFYGELGAINPTFIFPSAMRAKADLADQFVASMTMGCG QFCTKPGVVFALNTPETQAFIETAQSLIRQQSPSTLLTPG IRDSYQSQVVSRGSDDGIDVTFSQAESPCVASALFVTSSE NWRKHPAWEEEIFGPQSLIVVCENVADMLSLSEMLAGSLT ATIHATEEDYPQVSQLIPRLEEIAGRLVFNGWPTGVEVGY AMVHGGPYPASTHSASTSVGAEAIHRWLRPVAYQALPESL LPDSLKAENPLEIARAVDGKAA C:  NVFYATNAFTGEALPLAFPVHTEVEVNQAATAAAKVARDF RRLNNSKRASLLRTIASELEARSDDIIARAHLETALPEVR LTGEIARTANQLRLFADVVNSGSYHQAILDTPNPTRAPLP KPDIRRQQIALGPVAVFGASNFPLAFSAAGGDTASALAAG CPVIVKGHTAHPGTSQIVAECIEQALKQEQLPQAIFTLLQ GNQRALGQALVSHPEIKAVGFTGSVGGGRALFNLAHERPE PIPFYGELGAINPTFIFPSAMRAKADLADQFVASMTMGCG QFCTKPGVVFALNTPETQAFIETAQSLIRQQSPSTLLTPG IRDSYQSQVVSRGSDDGIDVTFSQAESPCVASALFVTSSE NWRKHPAWEEEIFGPQSLIVVCENVADMLSLSEMLAGSLT ATIHATEEDYPQVSQLIPRLEEIAGRLVFNGWPTGVEVGY AMVHGGPYPASTHSASTSVGAEAIHRWLRPVAYQALPESL LPDSLKAENPLEIARAVDGKAA D:  NVFYATNAFTGEALPLAFPVHTEVEVNQAATAAAKVARDF RRLNNSKRASLLRTIASELEARSDDIIARAHLETALPEVR LTGEIARTANQLRLFADVVNSGSYHQAILDTPNPTRAPLP KPDIRRQQIALGPVAVFGASNFPLAFSAAGGDTASALAAG CPVIVKGHTAHPGTSQIVAECIEQALKQEQLPQAIFTLLQ GNQRALGQALVSHPEIKAVGFTGSVGGGRALFNLAHERPE PIPFYGELGAINPTFIFPSAMRAKADLADQFVASMTMGCG QFCTKPGVVFALNTPETQAFIETAQSLIRQQSPSTLLTPG IRDSYQSQVVSRGSDDGIDVTFSQAESPCVASALFVTSSE NWRKHPAWEEEIFGPQSLIVVCENVADMLSLSEMLAGSLT ATIHATEEDYPQVSQLIPRLEEIAGRLVFNGWPTGVEVGY AMVHGGPYPASTHSASTSVGAEAIHRWLRPVAYQALPESL LPDSLKAENPLEIARAVDGKAA Description Functional site 1) chain A residue 253 type sequence E description THE KEY RESIDUES AROUND THE ACTIVE SITE source : CTA 2) chain A residue 289 type sequence C description THE KEY RESIDUES AROUND THE ACTIVE SITE source : CTA 3) chain A residue 172 type sequence K description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPA 4) chain A residue 175 type sequence T description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPA 5) chain A residue 210 type sequence R description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPA 6) chain A residue 377 type sequence E description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPA 7) chain B residue 253 type sequence E description THE KEY RESIDUES AROUND THE ACTIVE SITE source : CTB 8) chain B residue 289 type sequence C description THE KEY RESIDUES AROUND THE ACTIVE SITE source : CTB 9) chain B residue 172 type sequence K description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPB 10) chain B residue 175 type sequence T description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPB 11) chain B residue 210 type sequence R description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPB 12) chain B residue 377 type sequence E description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPB 13) chain C residue 253 type sequence E description THE KEY RESIDUES AROUND THE ACTIVE SITE source : CTC 14) chain C residue 289 type sequence C description THE KEY RESIDUES AROUND THE ACTIVE SITE source : CTC 15) chain C residue 172 type sequence K description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPC 16) chain C residue 175 type sequence T description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPC 17) chain C residue 210 type sequence R description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPC 18) chain C residue 377 type sequence E description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPC 19) chain D residue 253 type sequence E description THE KEY RESIDUES AROUND THE ACTIVE SITE source : CTD 20) chain D residue 289 type sequence C description THE KEY RESIDUES AROUND THE ACTIVE SITE source : CTD 21) chain D residue 172 type sequence K description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPD 22) chain D residue 175 type sequence T description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPD 23) chain D residue 210 type sequence R description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPD 24) chain D residue 377 type sequence E description KEY RESIDUES WHICH INTERACT WITH THE NADP+ COFACTOR source : NPD 25) chain A residue 146 type sequence S description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 26) chain A residue 147 type sequence N description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 27) chain A residue 172 type sequence K description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 28) chain A residue 174 type sequence H description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 29) chain A residue 175 type sequence T description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 30) chain A residue 210 type sequence R description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 31) chain A residue 214 type sequence Q description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 32) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 33) chain A residue 228 type sequence T description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 34) chain A residue 229 type sequence G description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 35) chain A residue 230 type sequence S description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 36) chain A residue 233 type sequence G description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 37) chain A residue 253 type sequence E description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 38) chain A residue 289 type sequence C description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 39) chain A residue 377 type sequence E description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 40) chain A residue 379 type sequence F description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 41) chain A residue 405 type sequence L description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 42) chain A residue 450 type sequence H description BINDING SITE FOR RESIDUE NAP A 650 source : AC1 43) chain A residue 6 type sequence D description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 44) chain B residue 143 type sequence F description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 45) chain B residue 146 type sequence S description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 46) chain B residue 147 type sequence N description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 47) chain B residue 172 type sequence K description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 48) chain B residue 174 type sequence H description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 49) chain B residue 175 type sequence T description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 50) chain B residue 210 type sequence R description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 51) chain B residue 214 type sequence Q description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 52) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 53) chain B residue 228 type sequence T description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 54) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 55) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 56) chain B residue 233 type sequence G description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 57) chain B residue 237 type sequence L description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 58) chain B residue 253 type sequence E description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 59) chain B residue 289 type sequence C description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 60) chain B residue 377 type sequence E description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 61) chain B residue 379 type sequence F description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 62) chain B residue 405 type sequence L description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 63) chain B residue 450 type sequence H description BINDING SITE FOR RESIDUE NAP B 750 source : AC2 64) chain C residue 146 type sequence S description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 65) chain C residue 147 type sequence N description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 66) chain C residue 172 type sequence K description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 67) chain C residue 174 type sequence H description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 68) chain C residue 175 type sequence T description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 69) chain C residue 210 type sequence R description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 70) chain C residue 214 type sequence Q description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 71) chain C residue 227 type sequence F description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 72) chain C residue 228 type sequence T description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 73) chain C residue 229 type sequence G description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 74) chain C residue 230 type sequence S description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 75) chain C residue 233 type sequence G description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 76) chain C residue 237 type sequence L description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 77) chain C residue 253 type sequence E description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 78) chain C residue 289 type sequence C description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 79) chain C residue 377 type sequence E description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 80) chain C residue 379 type sequence F description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 81) chain C residue 405 type sequence L description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 82) chain C residue 450 type sequence H description BINDING SITE FOR RESIDUE NAP C 850 source : AC3 83) chain D residue 146 type sequence S description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 84) chain D residue 147 type sequence N description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 85) chain D residue 172 type sequence K description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 86) chain D residue 174 type sequence H description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 87) chain D residue 175 type sequence T description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 88) chain D residue 210 type sequence R description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 89) chain D residue 214 type sequence Q description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 90) chain D residue 227 type sequence F description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 91) chain D residue 228 type sequence T description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 92) chain D residue 229 type sequence G description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 93) chain D residue 230 type sequence S description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 94) chain D residue 233 type sequence G description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 95) chain D residue 237 type sequence L description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 96) chain D residue 253 type sequence E description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 97) chain D residue 255 type sequence G description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 98) chain D residue 289 type sequence C description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 99) chain D residue 377 type sequence E description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 100) chain D residue 379 type sequence F description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 101) chain D residue 405 type sequence L description BINDING SITE FOR RESIDUE NAP D 950 source : AC4 102) chain A residue 253 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 103) chain A residue 289 type ACT_SITE sequence C description source Swiss-Prot : SWS_FT_FI1 104) chain B residue 253 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 105) chain B residue 289 type ACT_SITE sequence C description source Swiss-Prot : SWS_FT_FI1 106) chain C residue 253 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 107) chain C residue 289 type ACT_SITE sequence C description source Swiss-Prot : SWS_FT_FI1 108) chain D residue 253 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 109) chain D residue 289 type ACT_SITE sequence C description source Swiss-Prot : SWS_FT_FI1 110) chain A residue 229 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 111) chain B residue 229 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 112) chain C residue 229 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 113) chain D residue 229 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2

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