eF-site ID 1eye-A PDB Code 1eye Chain A click to enlarge Title 1.7 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF 6-HYDROXYMETHYL-7,8-DIHYDROPTEROATE SYNTHASE (DHPS) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH 6-HYDROXYMETHYLPTERIN MONOPHOSPHATE Classification TRANSFERASE Compound DIHYDROPTEROATE SYNTHASE I Source (DHP1_MYCTU) Sequence A:  PVQVMGVLNVTDDSFSDGGCYLDLDDAVKHGLAMAAAGAG IVDVGGETSRVIPVVKELAAQGITVSIDTMRADVARAALQ NGAQMVNDVSGGRADPAMGPLLAEADVPWVLMHWRAVSAD TPHVPVRYGNVVAEVRADLLASVADAVAAGVDPARLVLDP GLGFAKTAQHNWAILHALPELVATGIPVLVGASRKRFLGA LLAGPDGVMRPTDGRDTATAVISALAALHGAWGVRVHDVR ASVDAIKVVEAWMGAE Description Functional site 1) chain A residue 13 type sequence N description BINDING SITE FOR RESIDUE MG A 300 source : AC1 2) chain A residue 22 type sequence G description BINDING SITE FOR RESIDUE MG A 300 source : AC1 3) chain A residue 255 type sequence H description BINDING SITE FOR RESIDUE MG A 300 source : AC1 4) chain A residue 13 type sequence N description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 5) chain A residue 21 type sequence D description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 6) chain A residue 86 type sequence D description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 7) chain A residue 105 type sequence N description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 8) chain A residue 107 type sequence V description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 9) chain A residue 130 type sequence M description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 10) chain A residue 177 type sequence D description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 11) chain A residue 182 type sequence F description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 12) chain A residue 209 type sequence G description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 13) chain A residue 213 type sequence K description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 14) chain A residue 253 type sequence R description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 15) chain A residue 255 type sequence H description BINDING SITE FOR RESIDUE PMM A 301 source : AC2 16) chain A residue 8-23 type prosite sequence VMGVLNVTDDSFSDGG description DHPS_1 Dihydropteroate synthase signature 1. VmGVLNvTdDSFsDgG source prosite : PS00792 17) chain A residue 13 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11007651 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 21 type BINDING sequence D description BINDING => ECO:0000305|PubMed:11007651, ECO:0007744|PDB:1EYE source Swiss-Prot : SWS_FT_FI2 19) chain A residue 86 type BINDING sequence D description BINDING => ECO:0000305|PubMed:11007651, ECO:0007744|PDB:1EYE source Swiss-Prot : SWS_FT_FI2 20) chain A residue 105 type BINDING sequence N description BINDING => ECO:0000305|PubMed:11007651, ECO:0007744|PDB:1EYE source Swiss-Prot : SWS_FT_FI2 21) chain A residue 177 type BINDING sequence D description BINDING => ECO:0000305|PubMed:11007651, ECO:0007744|PDB:1EYE source Swiss-Prot : SWS_FT_FI2 22) chain A residue 213 type BINDING sequence K description BINDING => ECO:0000305|PubMed:11007651, ECO:0007744|PDB:1EYE source Swiss-Prot : SWS_FT_FI2 23) chain A residue 253 type BINDING sequence R description BINDING => ECO:0000305|PubMed:11007651, ECO:0007744|PDB:1EYE source Swiss-Prot : SWS_FT_FI2

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