eF-site ID 1ew9-AB PDB Code 1ew9 Chain A, B click to enlarge Title ALKALINE PHOSPHATASE (E.C. 3.1.3.1) COMPLEX WITH MERCAPTOMETHYL PHOSPHONATE Classification HYDROLASE Compound ALKALINE PHOSPHATASE Source Escherichia coli (strain K12) (PPB_ECOLI) Sequence A:  TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDK PAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPL TGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGAL GVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALV AHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARA DVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDA ASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNID KPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQ VEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEG NTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVM SYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFY TMKAALGLK B:  TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDK PAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPL TGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGAL GVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALV AHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARA DVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDA ASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNID KPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQ VEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEG NTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVM SYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFY TMKAALGLK Description Functional site 1) chain B residue 327 type sequence D description source : A 2) chain A residue 331 type sequence H description source : A 3) chain A residue 412 type sequence H description source : A 4) chain A residue 51 type sequence D description source : A 5) chain A residue 369 type sequence D description source : A 6) chain A residue 370 type sequence H description source : A 7) chain A residue 155 type sequence T description source : A 8) chain A residue 322 type sequence E description source : A 9) chain A residue 153 type sequence D description source : A 10) chain A residue 328 type sequence K description source : A 11) chain A residue 166 type sequence R description source : A 12) chain B residue 327 type sequence D description source : B 13) chain B residue 331 type sequence H description source : B 14) chain B residue 412 type sequence H description source : B 15) chain B residue 51 type sequence D description source : B 16) chain B residue 369 type sequence D description source : B 17) chain B residue 370 type sequence H description source : B 18) chain B residue 155 type sequence T description source : B 19) chain B residue 322 type sequence E description source : B 20) chain B residue 153 type sequence D description source : B 21) chain B residue 328 type sequence K description source : B 22) chain B residue 166 type sequence R description source : B 23) chain A residue 327 type sequence D description BINDING SITE FOR RESIDUE ZN A 450 source : AC1 24) chain A residue 331 type sequence H description BINDING SITE FOR RESIDUE ZN A 450 source : AC1 25) chain A residue 412 type sequence H description BINDING SITE FOR RESIDUE ZN A 450 source : AC1 26) chain A residue 51 type sequence D description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 27) chain A residue 102 type sequence S description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 28) chain A residue 369 type sequence D description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 29) chain A residue 370 type sequence H description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 30) chain A residue 267 type sequence R description BINDING SITE FOR RESIDUE SO4 A 558 source : AC3 31) chain A residue 268 type sequence W description BINDING SITE FOR RESIDUE SO4 A 558 source : AC3 32) chain A residue 292 type sequence R description BINDING SITE FOR RESIDUE SO4 A 558 source : AC3 33) chain B residue 449 type sequence K description BINDING SITE FOR RESIDUE SO4 A 558 source : AC3 34) chain B residue 327 type sequence D description BINDING SITE FOR RESIDUE ZN B 450 source : AC4 35) chain B residue 331 type sequence H description BINDING SITE FOR RESIDUE ZN B 450 source : AC4 36) chain B residue 412 type sequence H description BINDING SITE FOR RESIDUE ZN B 450 source : AC4 37) chain B residue 51 type sequence D description BINDING SITE FOR RESIDUE ZN B 451 source : AC5 38) chain B residue 102 type sequence S description BINDING SITE FOR RESIDUE ZN B 451 source : AC5 39) chain B residue 369 type sequence D description BINDING SITE FOR RESIDUE ZN B 451 source : AC5 40) chain B residue 370 type sequence H description BINDING SITE FOR RESIDUE ZN B 451 source : AC5 41) chain B residue 267 type sequence R description BINDING SITE FOR RESIDUE SO4 B 958 source : AC6 42) chain B residue 268 type sequence W description BINDING SITE FOR RESIDUE SO4 B 958 source : AC6 43) chain B residue 292 type sequence R description BINDING SITE FOR RESIDUE SO4 B 958 source : AC6 44) chain A residue 51 type sequence D description BINDING SITE FOR RESIDUE MG A 452 source : AC7 45) chain A residue 155 type sequence T description BINDING SITE FOR RESIDUE MG A 452 source : AC7 46) chain A residue 322 type sequence E description BINDING SITE FOR RESIDUE MG A 452 source : AC7 47) chain A residue 51 type sequence D description BINDING SITE FOR RESIDUE ZN A 453 source : AC8 48) chain A residue 155 type sequence T description BINDING SITE FOR RESIDUE ZN A 453 source : AC8 49) chain A residue 322 type sequence E description BINDING SITE FOR RESIDUE ZN A 453 source : AC8 50) chain B residue 51 type sequence D description BINDING SITE FOR RESIDUE MG B 452 source : AC9 51) chain B residue 153 type sequence D description BINDING SITE FOR RESIDUE MG B 452 source : AC9 52) chain B residue 155 type sequence T description BINDING SITE FOR RESIDUE MG B 452 source : AC9 53) chain B residue 322 type sequence E description BINDING SITE FOR RESIDUE MG B 452 source : AC9 54) chain B residue 51 type sequence D description BINDING SITE FOR RESIDUE ZN B 453 source : BC1 55) chain B residue 153 type sequence D description BINDING SITE FOR RESIDUE ZN B 453 source : BC1 56) chain B residue 155 type sequence T description BINDING SITE FOR RESIDUE ZN B 453 source : BC1 57) chain B residue 322 type sequence E description BINDING SITE FOR RESIDUE ZN B 453 source : BC1 58) chain A residue 101 type sequence D description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 59) chain A residue 102 type sequence S description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 60) chain A residue 166 type sequence R description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 61) chain A residue 327 type sequence D description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 62) chain A residue 331 type sequence H description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 63) chain A residue 412 type sequence H description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 64) chain B residue 101 type sequence D description BINDING SITE FOR RESIDUE MMQ B 559 source : BC3 65) chain B residue 102 type sequence S description BINDING SITE FOR RESIDUE MMQ B 559 source : BC3 66) chain B residue 166 type sequence R description BINDING SITE FOR RESIDUE MMQ B 559 source : BC3 67) chain B residue 327 type sequence D description BINDING SITE FOR RESIDUE MMQ B 559 source : BC3 68) chain B residue 331 type sequence H description BINDING SITE FOR RESIDUE MMQ B 559 source : BC3 69) chain B residue 412 type sequence H description BINDING SITE FOR RESIDUE MMQ B 559 source : BC3 70) chain A residue 51 type catalytic sequence D description 44 source MCSA : MCSA1 71) chain A residue 369 type catalytic sequence D description 44 source MCSA : MCSA1 72) chain A residue 370 type catalytic sequence H description 44 source MCSA : MCSA1 73) chain A residue 412 type catalytic sequence H description 44 source MCSA : MCSA1 74) chain A residue 102 type catalytic sequence S description 44 source MCSA : MCSA1 75) chain A residue 153 type catalytic sequence D description 44 source MCSA : MCSA1 76) chain A residue 155 type catalytic sequence T description 44 source MCSA : MCSA1 77) chain A residue 166 type catalytic sequence R description 44 source MCSA : MCSA1 78) chain A residue 322 type catalytic sequence E description 44 source MCSA : MCSA1 79) chain A residue 327 type catalytic sequence D description 44 source MCSA : MCSA1 80) chain A residue 328 type catalytic sequence K description 44 source MCSA : MCSA1 81) chain A residue 331 type catalytic sequence H description 44 source MCSA : MCSA1 82) chain B residue 51 type catalytic sequence D description 44 source MCSA : MCSA2 83) chain B residue 369 type catalytic sequence D description 44 source MCSA : MCSA2 84) chain B residue 370 type catalytic sequence H description 44 source MCSA : MCSA2 85) chain B residue 412 type catalytic sequence H description 44 source MCSA : MCSA2 86) chain B residue 102 type catalytic sequence S description 44 source MCSA : MCSA2 87) chain B residue 153 type catalytic sequence D description 44 source MCSA : MCSA2 88) chain B residue 155 type catalytic sequence T description 44 source MCSA : MCSA2 89) chain B residue 166 type catalytic sequence R description 44 source MCSA : MCSA2 90) chain B residue 322 type catalytic sequence E description 44 source MCSA : MCSA2 91) chain B residue 327 type catalytic sequence D description 44 source MCSA : MCSA2 92) chain B residue 328 type catalytic sequence K description 44 source MCSA : MCSA2 93) chain B residue 331 type catalytic sequence H description 44 source MCSA : MCSA2 94) chain A residue 51 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 95) chain B residue 51 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 96) chain B residue 153 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 97) chain B residue 155 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 98) chain B residue 322 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 99) chain B residue 327 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 100) chain B residue 331 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 101) chain B residue 369 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 102) chain B residue 370 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 103) chain B residue 412 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 104) chain A residue 153 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 105) chain A residue 155 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 106) chain A residue 322 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 107) chain A residue 327 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 108) chain A residue 331 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 109) chain A residue 369 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 110) chain A residue 370 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 111) chain A residue 412 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 112) chain A residue 102 type ACT_SITE sequence S description Phosphoserine intermediate source Swiss-Prot : SWS_FT_FI1 113) chain B residue 102 type ACT_SITE sequence S description Phosphoserine intermediate source Swiss-Prot : SWS_FT_FI1 114) chain A residue 99-107 type prosite sequence VTDSAASAT description ALKALINE_PHOSPHATASE Alkaline phosphatase active site. VtDSAASAT source prosite : PS00123

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