eF-site ID 1ew9-A PDB Code 1ew9 Chain A click to enlarge Title ALKALINE PHOSPHATASE (E.C. 3.1.3.1) COMPLEX WITH MERCAPTOMETHYL PHOSPHONATE Classification HYDROLASE Compound ALKALINE PHOSPHATASE Source Escherichia coli (strain K12) (PPB_ECOLI) Sequence A:  TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDK PAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPL TGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGAL GVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALV AHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARA DVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDA ASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNID KPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQ VEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEG NTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVM SYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFY TMKAALGLK Description Functional site 1) chain A residue 331 type sequence H description source : A 2) chain A residue 412 type sequence H description source : A 3) chain A residue 51 type sequence D description source : A 4) chain A residue 369 type sequence D description source : A 5) chain A residue 370 type sequence H description source : A 6) chain A residue 155 type sequence T description source : A 7) chain A residue 322 type sequence E description source : A 8) chain A residue 153 type sequence D description source : A 9) chain A residue 328 type sequence K description source : A 10) chain A residue 166 type sequence R description source : A 11) chain A residue 327 type sequence D description BINDING SITE FOR RESIDUE ZN A 450 source : AC1 12) chain A residue 331 type sequence H description BINDING SITE FOR RESIDUE ZN A 450 source : AC1 13) chain A residue 412 type sequence H description BINDING SITE FOR RESIDUE ZN A 450 source : AC1 14) chain A residue 51 type sequence D description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 15) chain A residue 102 type sequence S description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 16) chain A residue 369 type sequence D description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 17) chain A residue 370 type sequence H description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 18) chain A residue 267 type sequence R description BINDING SITE FOR RESIDUE SO4 A 558 source : AC3 19) chain A residue 268 type sequence W description BINDING SITE FOR RESIDUE SO4 A 558 source : AC3 20) chain A residue 292 type sequence R description BINDING SITE FOR RESIDUE SO4 A 558 source : AC3 21) chain A residue 51 type sequence D description BINDING SITE FOR RESIDUE MG A 452 source : AC7 22) chain A residue 155 type sequence T description BINDING SITE FOR RESIDUE MG A 452 source : AC7 23) chain A residue 322 type sequence E description BINDING SITE FOR RESIDUE MG A 452 source : AC7 24) chain A residue 51 type sequence D description BINDING SITE FOR RESIDUE ZN A 453 source : AC8 25) chain A residue 155 type sequence T description BINDING SITE FOR RESIDUE ZN A 453 source : AC8 26) chain A residue 322 type sequence E description BINDING SITE FOR RESIDUE ZN A 453 source : AC8 27) chain A residue 101 type sequence D description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 28) chain A residue 102 type sequence S description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 29) chain A residue 166 type sequence R description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 30) chain A residue 327 type sequence D description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 31) chain A residue 331 type sequence H description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 32) chain A residue 412 type sequence H description BINDING SITE FOR RESIDUE MMQ A 559 source : BC2 33) chain A residue 51 type catalytic sequence D description 44 source MCSA : MCSA1 34) chain A residue 369 type catalytic sequence D description 44 source MCSA : MCSA1 35) chain A residue 370 type catalytic sequence H description 44 source MCSA : MCSA1 36) chain A residue 412 type catalytic sequence H description 44 source MCSA : MCSA1 37) chain A residue 102 type catalytic sequence S description 44 source MCSA : MCSA1 38) chain A residue 153 type catalytic sequence D description 44 source MCSA : MCSA1 39) chain A residue 155 type catalytic sequence T description 44 source MCSA : MCSA1 40) chain A residue 166 type catalytic sequence R description 44 source MCSA : MCSA1 41) chain A residue 322 type catalytic sequence E description 44 source MCSA : MCSA1 42) chain A residue 327 type catalytic sequence D description 44 source MCSA : MCSA1 43) chain A residue 328 type catalytic sequence K description 44 source MCSA : MCSA1 44) chain A residue 331 type catalytic sequence H description 44 source MCSA : MCSA1 45) chain A residue 51 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 46) chain A residue 153 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 47) chain A residue 155 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 48) chain A residue 322 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 49) chain A residue 327 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 50) chain A residue 331 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 51) chain A residue 369 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 52) chain A residue 370 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 53) chain A residue 412 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 54) chain A residue 102 type ACT_SITE sequence S description Phosphoserine intermediate source Swiss-Prot : SWS_FT_FI1 55) chain A residue 99-107 type prosite sequence VTDSAASAT description ALKALINE_PHOSPHATASE Alkaline phosphatase active site. VtDSAASAT source prosite : PS00123

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