eF-site ID 1eut-A PDB Code 1eut Chain A click to enlarge Title SIALIDASE, LARGE 68KD FORM, COMPLEXED WITH GALACTOSE Classification HYDROLASE Compound SIALIDASE Source ORGANISM_SCIENTIFIC: Micromonospora viridifaciens; Sequence A:  GEPLYTEQDLAVNGREGFPNYRIPALTVTPDGDLLASYDG RPTGIDAPGPNSILQRRSTDGGRTWGEQQVVSAGQTTAPI KGFSDPSYLVDRETGTIFNFHVYSQRQGFAGSRPGTDPAD PNVLHANVATSTDGGLTWSHRTITADITPDPGWRSRFAAS GEGIQLRYGPHAGRLIQQYTIINAAGAFQAVSVYSDDHGR TWRAGEAVGVGMDENKTVELSDGRVLLNSRDSARSGYRKV AVSTDGGHSYGPVTIDRDLPDPTNNASIIRAFPDAPAGSA RAKVLLFSNAASQTSRSQGTIRMSCDDGQTWPVSKVFQPG SMSYSTLTALPDGTYGLLYEPGTGIRYANFNLAWLGGICA PFTIPDVALEPGQQVTVPVAVTNQSGIAVPKPSLQLDASP DWQVQGSVEPLMPGRQAKGQVTITVPAGTTPGRYRVGATL RTSAGNASTTFTVTVGLLDQARMSIADVDSEETAREDGRA SNVIDGNPSTFWHTEWSRADAPGYPHRISLDLGGTHTISG LQYTRRQNSANEQVADYEIYTSLNGTTWDGPVASGRFTTS LAPQRAVFPARDARYIRLVALSEQTGHKYAAVAELEVEGQ R Description (1)  SIALIDASE Functional site 1) chain A residue 224 type sequence Q description ACTIVE SITE. SITE INCLUDES TWO CONTACTS WITH SYMMETRY-RELATED MOLECULES. source : ACT 2) chain A residue 245 type sequence G description ACTIVE SITE. SITE INCLUDES TWO CONTACTS WITH SYMMETRY-RELATED MOLECULES. source : ACT 3) chain A residue 250 type sequence A description ACTIVE SITE. SITE INCLUDES TWO CONTACTS WITH SYMMETRY-RELATED MOLECULES. source : ACT 4) chain A residue 292 type sequence G description ACTIVE SITE. SITE INCLUDES TWO CONTACTS WITH SYMMETRY-RELATED MOLECULES. source : ACT 5) chain A residue 311 type sequence N description ACTIVE SITE. SITE INCLUDES TWO CONTACTS WITH SYMMETRY-RELATED MOLECULES. source : ACT 6) chain A residue 318 type sequence F description ACTIVE SITE. SITE INCLUDES TWO CONTACTS WITH SYMMETRY-RELATED MOLECULES. source : ACT 7) chain A residue 619 type sequence A description ACTIVE SITE. SITE INCLUDES TWO CONTACTS WITH SYMMETRY-RELATED MOLECULES. source : ACT 8) chain A residue 635 type sequence Y description ACTIVE SITE. SITE INCLUDES TWO CONTACTS WITH SYMMETRY-RELATED MOLECULES. source : ACT 9) chain A residue 637 type sequence A description ACTIVE SITE. SITE INCLUDES TWO CONTACTS WITH SYMMETRY-RELATED MOLECULES. source : ACT 10) chain A residue 528 type sequence N description BINDING SITE FOR RESIDUE NA A 1 source : AC1 11) chain A residue 531 type sequence D description BINDING SITE FOR RESIDUE NA A 1 source : AC1 12) chain A residue 533 type sequence N description BINDING SITE FOR RESIDUE NA A 1 source : AC1 13) chain A residue 536 type sequence T description BINDING SITE FOR RESIDUE NA A 1 source : AC1 14) chain A residue 639 type sequence A description BINDING SITE FOR RESIDUE NA A 1 source : AC1 15) chain A residue 640 type sequence E description BINDING SITE FOR RESIDUE NA A 1 source : AC1 16) chain A residue 92 type catalytic sequence D description 835 source MCSA : MCSA1 17) chain A residue 260 type catalytic sequence E description 835 source MCSA : MCSA1 18) chain A residue 370 type catalytic sequence Y description 835 source MCSA : MCSA1 19) chain A residue 92 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 260 type ACT_SITE sequence E description Nucleophile => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 370 type ACT_SITE sequence Y description Nucleophile source Swiss-Prot : SWS_FT_FI3 22) chain A residue 68 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 23) chain A residue 276 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4

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