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eF-site ID
|
1ekm-C |
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PDB Code
|
1ekm |
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Chain
|
C |
|
click to enlarge
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Title
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CRYSTAL STRUCTURE AT 2.5 A RESOLUTION OF ZINC-SUBSTITUTED COPPER AMINE OXIDASE OF HANSENULA POLYMORPHA EXPRESSED IN ESCHERICHIA COLI |
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Classification
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OXIDOREDUCTASE |
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Compound
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COPPER AMINE OXIDASE |
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Source
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Pichia angusta (Yeast) (Hansenula polymorpha) (AMO_PICAN) |
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Sequence
|
C: |
APARPAHPLDPLSTAEIKAATNTVKSYFAGKKISFNTVTL
REPARKAYIQWKEQGGPLPPRLAYYVILEAGKPGVKEGLV
DLASLSVIETRALETVQPILTVEDLCSTEEVIRNDPAVIE
QCVLSGIPANEMHKVYCDPWTIGYDERWGTGKRLQQALVY
YRSDEDDSQYSHPLDFCPIVDTEEKKVIFIDIPNRRRKVS
KHKHANFYPKHMIEKVGAMRPEAPPINVTQPEGVSFKMTG
NVMEWSNFKFHIGFNYREGIVLSDVSYNDHGNVRPIFHRI
SLSEMIVPYGSPEFPHQRKHALDIGEYGAGYMTNPLSLGC
DCKGVIHYLDAHFSDRAGDPITVKNAVCIHEEDDGLLFKH
SDFRDNFATSLVTRATKLVVSQIFTAANYEYCLYWVFMQD
GAIRLDIRLTGILNTYILGDDEEAGPWGTRVYPNVNAHNH
QHLFSLRIDPRIDGDGNSAAACDAKSSPYPLGSPENMYGN
AFYSEKTTFKTVKDSLTNYESATGRSWDIFNPNKVNPYSG
KPPSYKLVSTQCPPLLAKEGSLVAKRAPWASHSVNVVPYK
DNRLYPSGDHVPQWSGDGVRGMREWIGDGSENIDNTDILF
FHTFGITHFPAPEDFPLMPAEPITLMLRPRHFFTENPGLD
IQPSYAMTTSEAKRAV
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Description
|
(1) |
COPPER AMINE OXIDASE (E.C.1.4.3.6)
|
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Functional site
|
|
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1)
|
chain |
C |
| residue |
405 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE ZN C 701
|
| source |
: AC3
|
|
|
2)
|
chain |
C |
| residue |
456 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN C 701
|
| source |
: AC3
|
|
|
3)
|
chain |
C |
| residue |
458 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN C 701
|
| source |
: AC3
|
|
|
4)
|
chain |
C |
| residue |
624 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN C 701
|
| source |
: AC3
|
|
|
5)
|
chain |
C |
| residue |
456 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10933787, ECO:0000269|PubMed:9551552, ECO:0007744|PDB:1A2V, ECO:0007744|PDB:1EKM, ECO:0007744|PDB:2OOV, ECO:0007744|PDB:2OQE, ECO:0007744|PDB:3N9H, ECO:0007744|PDB:3NBB, ECO:0007744|PDB:3NBJ, ECO:0007744|PDB:3T0U, ECO:0007744|PDB:4EV2, ECO:0007744|PDB:4EV5, ECO:0007744|PDB:4KFD, ECO:0007744|PDB:4KFE, ECO:0007744|PDB:4KFF
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
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6)
|
chain |
C |
| residue |
458 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10933787, ECO:0000269|PubMed:9551552, ECO:0007744|PDB:1A2V, ECO:0007744|PDB:1EKM, ECO:0007744|PDB:2OOV, ECO:0007744|PDB:2OQE, ECO:0007744|PDB:3N9H, ECO:0007744|PDB:3NBB, ECO:0007744|PDB:3NBJ, ECO:0007744|PDB:3T0U, ECO:0007744|PDB:4EV2, ECO:0007744|PDB:4EV5, ECO:0007744|PDB:4KFD, ECO:0007744|PDB:4KFE, ECO:0007744|PDB:4KFF
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
7)
|
chain |
C |
| residue |
624 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10933787, ECO:0000269|PubMed:9551552, ECO:0007744|PDB:1A2V, ECO:0007744|PDB:1EKM, ECO:0007744|PDB:2OOV, ECO:0007744|PDB:2OQE, ECO:0007744|PDB:3N9H, ECO:0007744|PDB:3NBB, ECO:0007744|PDB:3NBJ, ECO:0007744|PDB:3T0U, ECO:0007744|PDB:4EV2, ECO:0007744|PDB:4EV5, ECO:0007744|PDB:4KFD, ECO:0007744|PDB:4KFE, ECO:0007744|PDB:4KFF
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
8)
|
chain |
C |
| residue |
465 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:Q43077
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
9)
|
chain |
C |
| residue |
613 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:Q43077
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
10)
|
chain |
C |
| residue |
614 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000250|UniProtKB:Q43077
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
11)
|
chain |
C |
| residue |
319 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000269|PubMed:9551552
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
12)
|
chain |
C |
| residue |
405 |
| type |
ACT_SITE |
| sequence |
Y
|
| description |
Schiff-base intermediate with substrate; via topaquinone => ECO:0000269|PubMed:10933787, ECO:0000269|PubMed:9551552, ECO:0007744|PDB:1EKM, ECO:0007744|PDB:3NBB, ECO:0007744|PDB:3NBJ, ECO:0007744|PDB:3T0U, ECO:0007744|PDB:4KFF
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
13)
|
chain |
C |
| residue |
405 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
2',4',5'-topaquinone => ECO:0000269|PubMed:9551552, ECO:0007744|PDB:1A2V, ECO:0007744|PDB:2OQE
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
14)
|
chain |
C |
| residue |
243 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:9551552
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
15)
|
chain |
C |
| residue |
317 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0007744|PDB:4EV2, ECO:0007744|PDB:4EV5
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
16)
|
chain |
C |
| residue |
402 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0000250|UniProtKB:P46883
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
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