eF-site ID 1eh8-A PDB Code 1eh8 Chain A click to enlarge Title BENZYLATED HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE Classification TRANSFERASE Compound O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE Source null (MGMT_HUMAN) Sequence A:  CEMKRTTLDSPLGKLELSGCEQGLHEIKLLGEVPAPAAVL GGPEPLMQCTAWLNAYFHQPEAIEEFPVPALHHPVFQQES FTRQVLWKLLKVVKFGEVISYQQLAALAGNPKAARAVGGA MRGNPVPILIPXHRVVCSSGAVGNYSGGLAVKEWLLAHEG HRLGKP Description Functional site 1) chain A residue 145 type sequence X description ACTIVE SITE CYSTEINE, BENZYLATED source : ACT 2) chain A residue 5 type sequence C description BINDING SITE FOR RESIDUE ZN A 208 source : AC1 3) chain A residue 24 type sequence C description BINDING SITE FOR RESIDUE ZN A 208 source : AC1 4) chain A residue 29 type sequence H description BINDING SITE FOR RESIDUE ZN A 208 source : AC1 5) chain A residue 85 type sequence H description BINDING SITE FOR RESIDUE ZN A 208 source : AC1 6) chain A residue 114 type catalytic sequence Y description 251 source MCSA : MCSA1 7) chain A residue 137 type catalytic sequence N description 251 source MCSA : MCSA1 8) chain A residue 145 type catalytic sequence X description 251 source MCSA : MCSA1 9) chain A residue 146 type catalytic sequence H description 251 source MCSA : MCSA1 10) chain A residue 172 type catalytic sequence E description 251 source MCSA : MCSA1 11) chain A residue 143-149 type prosite sequence IPXHRVV description MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV source prosite : PS00374 12) chain A residue 123 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10747039, ECO:0000269|PubMed:15964013 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 128 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10747039, ECO:0000269|PubMed:15964013 source Swiss-Prot : SWS_FT_FI3 14) chain A residue 151 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10747039, ECO:0000269|PubMed:15964013 source Swiss-Prot : SWS_FT_FI3 15) chain A residue 95 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10747039, ECO:0000269|PubMed:15964013 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 114 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10747039, ECO:0000269|PubMed:15964013 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 115 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:10747039, ECO:0000269|PubMed:15964013 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 14 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 19) chain A residue 145 type ACT_SITE sequence X description Nucleophile; methyl group acceptor source Swiss-Prot : SWS_FT_FI1 20) chain A residue 5 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI2 21) chain A residue 24 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI2 22) chain A residue 29 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 23) chain A residue 85 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2

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