eF-site ID 1efx-ABCDE PDB Code 1efx Chain A, B, C, D, E click to enlarge Title STRUCTURE OF A COMPLEX BETWEEN THE HUMAN NATURAL KILLER CELL RECEPTOR KIR2DL2 AND A CLASS I MHC LIGAND HLA-CW3 Classification IMMUNE SYSTEM Compound HLA-CW3 (HEAVY CHAIN) Source null (KI2L2_HUMAN) Sequence A:  GSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDA ASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRN LRGYYNQSEAGSHIIQRMYGCDVGPDGRLLRGYDQYAYDG KDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYL EGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEAT LRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGT FQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSS B:  MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDL LKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYA CRVNHVTLSQPKIVKWDRDM C:  GAVDPLLAL D:  VHRKPSLLAHPGRLVKSEETVILQCWSDVRFEHFLLHREG KFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSV THSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGES VTLSCSSRSSYDMYHLSREGEAHECRFSAGPKVNGTFQAD FPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVI E:  VHRKPSLLAHPGRLVKSEETVILQCWSDVRFEHFLLHREG KFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSV THSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGES VTLSCSSRSSYDMYHLSREGEAHECRFSAGPKVNGTFQAD FPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVI Description Functional site 1) chain A residue 63 type BINDING sequence E description BINDING => ECO:0000269|PubMed:28649982 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 171 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:28649982 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 70 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:28649982 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 77 type BINDING sequence S description BINDING => ECO:0000269|PubMed:28649982 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 159 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:28649982 source Swiss-Prot : SWS_FT_FI1 6) chain E residue 190 type BINDING sequence N description BINDING => ECO:0000269|PubMed:28649982 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 86 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI2 8) chain B residue 19 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 9) chain B residue 41 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 10) chain B residue 48 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 11) chain B residue 58 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 91 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 13) chain B residue 94 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 78-84 type prosite sequence YACRVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH source prosite : PS00290 15) chain A residue 257-263 type prosite sequence YTCHVQH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH source prosite : PS00290

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