eF-site ID 1efh-AB
PDB Code 1efh
Chain A, B

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Title CRYSTAL STRUCTURE OF THE HUMAN HYDROXYSTEROID SULFOTRANSFERASE IN THE PRESENCE OF PAP
Classification TRANSFERASE
Compound HYDROXYSTEROID SULFOTRANSFERASE
Source (ST2A1_HUMAN)
Sequence A:  DFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYP
KSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIG
YTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNP
RDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSW
FDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLG
KTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVVDQL
LRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRKLAAAL
E
B:  DFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYP
KSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIG
YTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNP
RDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSW
FDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLG
KTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVKAQL
LRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRKLAAAL
EH
Description


Functional site

1) chain B
residue 44
type
sequence K
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

2) chain B
residue 45
type
sequence S
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

3) chain B
residue 46
type
sequence G
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

4) chain B
residue 47
type
sequence T
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

5) chain B
residue 48
type
sequence N
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

6) chain B
residue 49
type
sequence W
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

7) chain B
residue 121
type
sequence R
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

8) chain B
residue 129
type
sequence S
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

9) chain B
residue 184
type
sequence Y
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

10) chain B
residue 218
type
sequence S
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

11) chain B
residue 219
type
sequence S
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

12) chain B
residue 220
type
sequence F
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

13) chain B
residue 223
type
sequence M
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

14) chain B
residue 245
type
sequence L
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

15) chain B
residue 246
type
sequence L
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

16) chain B
residue 247
type
sequence R
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

17) chain B
residue 248
type
sequence K
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

18) chain B
residue 249
type
sequence G
description BINDING SITE FOR RESIDUE A3P B 302
source : AC1

19) chain A
residue 44
type
sequence K
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

20) chain A
residue 45
type
sequence S
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

21) chain A
residue 46
type
sequence G
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

22) chain A
residue 47
type
sequence T
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

23) chain A
residue 48
type
sequence N
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

24) chain A
residue 49
type
sequence W
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

25) chain A
residue 121
type
sequence R
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

26) chain A
residue 129
type
sequence S
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

27) chain A
residue 184
type
sequence Y
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

28) chain A
residue 218
type
sequence S
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

29) chain A
residue 219
type
sequence S
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

30) chain A
residue 220
type
sequence F
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

31) chain A
residue 223
type
sequence M
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

32) chain A
residue 245
type
sequence L
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

33) chain A
residue 246
type
sequence L
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

34) chain A
residue 247
type
sequence R
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

35) chain A
residue 248
type
sequence K
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

36) chain A
residue 249
type
sequence G
description BINDING SITE FOR RESIDUE A3P A 303
source : AC2

37) chain A
residue 99
type ACT_SITE
sequence H
description Proton acceptor => ECO:0000269|PubMed:11988089, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1J99, ECO:0007744|PDB:1OV4
source Swiss-Prot : SWS_FT_FI1

38) chain B
residue 99
type ACT_SITE
sequence H
description Proton acceptor => ECO:0000269|PubMed:11988089, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1J99, ECO:0007744|PDB:1OV4
source Swiss-Prot : SWS_FT_FI1

39) chain A
residue 44
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI2

40) chain A
residue 46
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI2

41) chain A
residue 48
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI2

42) chain B
residue 44
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI2

43) chain B
residue 46
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI2

44) chain B
residue 48
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI2

45) chain A
residue 45
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

46) chain B
residue 45
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

47) chain B
residue 47
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

48) chain B
residue 49
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

49) chain B
residue 121
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

50) chain B
residue 129
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

51) chain B
residue 218
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

52) chain B
residue 247
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

53) chain B
residue 248
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

54) chain B
residue 249
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

55) chain A
residue 47
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

56) chain A
residue 49
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

57) chain A
residue 121
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

58) chain A
residue 129
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

59) chain A
residue 218
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

60) chain A
residue 247
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

61) chain A
residue 248
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

62) chain A
residue 249
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI3

63) chain A
residue 184
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI4

64) chain B
residue 184
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI4

65) chain A
residue 223
type BINDING
sequence M
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI5

66) chain B
residue 223
type BINDING
sequence M
description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:4IFB
source Swiss-Prot : SWS_FT_FI5

67) chain A
residue 251
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI6

68) chain B
residue 251
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI6


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