eF-site ID 1efh-AB PDB Code 1efh Chain A, B click to enlarge Title CRYSTAL STRUCTURE OF THE HUMAN HYDROXYSTEROID SULFOTRANSFERASE IN THE PRESENCE OF PAP Classification TRANSFERASE Compound HYDROXYSTEROID SULFOTRANSFERASE Source (ST2A1_HUMAN) Sequence A:  DFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYP KSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIG YTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNP RDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSW FDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLG KTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVVDQL LRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRKLAAAL E B:  DFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYP KSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIG YTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNP RDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSW FDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLG KTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVKAQL LRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRKLAAAL EH Description Functional site 1) chain B residue 44 type sequence K description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 2) chain B residue 45 type sequence S description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 3) chain B residue 46 type sequence G description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 4) chain B residue 47 type sequence T description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 5) chain B residue 48 type sequence N description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 6) chain B residue 49 type sequence W description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 7) chain B residue 121 type sequence R description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 8) chain B residue 129 type sequence S description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 9) chain B residue 184 type sequence Y description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 10) chain B residue 218 type sequence S description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 11) chain B residue 219 type sequence S description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 12) chain B residue 220 type sequence F description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 13) chain B residue 223 type sequence M description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 14) chain B residue 245 type sequence L description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 15) chain B residue 246 type sequence L description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 16) chain B residue 247 type sequence R description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 17) chain B residue 248 type sequence K description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 18) chain B residue 249 type sequence G description BINDING SITE FOR RESIDUE A3P B 302 source : AC1 19) chain A residue 44 type sequence K description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 20) chain A residue 45 type sequence S description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 21) chain A residue 46 type sequence G description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 22) chain A residue 47 type sequence T description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 23) chain A residue 48 type sequence N description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 24) chain A residue 49 type sequence W description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 25) chain A residue 121 type sequence R description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 26) chain A residue 129 type sequence S description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 27) chain A residue 184 type sequence Y description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 28) chain A residue 218 type sequence S description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 29) chain A residue 219 type sequence S description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 30) chain A residue 220 type sequence F description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 31) chain A residue 223 type sequence M description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 32) chain A residue 245 type sequence L description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 33) chain A residue 246 type sequence L description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 34) chain A residue 247 type sequence R description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 35) chain A residue 248 type sequence K description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 36) chain A residue 249 type sequence G description BINDING SITE FOR RESIDUE A3P A 303 source : AC2 37) chain A residue 99 type ACT_SITE sequence H description Proton acceptor => ECO:0000269|PubMed:11988089, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1J99, ECO:0007744|PDB:1OV4 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 99 type ACT_SITE sequence H description Proton acceptor => ECO:0000269|PubMed:11988089, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1J99, ECO:0007744|PDB:1OV4 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 44 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI2 40) chain A residue 46 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI2 41) chain A residue 48 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI2 42) chain B residue 44 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI2 43) chain B residue 46 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI2 44) chain B residue 48 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI2 45) chain A residue 45 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 46) chain B residue 45 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 47) chain B residue 47 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 48) chain B residue 49 type BINDING sequence W description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 49) chain B residue 121 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 50) chain B residue 129 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 51) chain B residue 218 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 52) chain B residue 247 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 53) chain B residue 248 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 54) chain B residue 249 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 55) chain A residue 47 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 56) chain A residue 49 type BINDING sequence W description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 57) chain A residue 121 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 58) chain A residue 129 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 59) chain A residue 218 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 60) chain A residue 247 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 61) chain A residue 248 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 62) chain A residue 249 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI3 63) chain A residue 184 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI4 64) chain B residue 184 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI4 65) chain A residue 223 type BINDING sequence M description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI5 66) chain B residue 223 type BINDING sequence M description BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:4IFB source Swiss-Prot : SWS_FT_FI5 67) chain A residue 251 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6 68) chain B residue 251 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6

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