eF-site ID 1ed9-AB PDB Code 1ed9 Chain A, B click to enlarge Title STRUCTURE OF E. COLI ALKALINE PHOSPHATASE WITHOUT THE INORGANIC PHOSPHATE AT 1.75A RESOLUTION Classification HYDROLASE Compound ALKALINE PHOSPHATASE Source Escherichia coli (strain K12) (PPB_ECOLI) Sequence A:  TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDK PAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPL TGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGAL GVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALV AHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARA DVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDA ASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNID KPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQ VEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEG NTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVM SYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFY TMKAALGLK B:  TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDK PAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPL TGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGAL GVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALV AHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARA DVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDA ASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNID KPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQ VEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEG NTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVM SYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFY TMKAALGLK Description (1)  ALKALINE PHOSPHATASE (E.C.3.1.3.1) Functional site 1) chain A residue 327 type sequence D description BINDING SITE FOR RESIDUE ZN A 450 source : AC1 2) chain A residue 331 type sequence H description BINDING SITE FOR RESIDUE ZN A 450 source : AC1 3) chain A residue 412 type sequence H description BINDING SITE FOR RESIDUE ZN A 450 source : AC1 4) chain A residue 51 type sequence D description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 5) chain A residue 102 type sequence S description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 6) chain A residue 327 type sequence D description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 7) chain A residue 369 type sequence D description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 8) chain A residue 370 type sequence H description BINDING SITE FOR RESIDUE ZN A 451 source : AC2 9) chain A residue 51 type sequence D description BINDING SITE FOR RESIDUE MG A 462 source : AC3 10) chain A residue 155 type sequence T description BINDING SITE FOR RESIDUE MG A 462 source : AC3 11) chain A residue 322 type sequence E description BINDING SITE FOR RESIDUE MG A 462 source : AC3 12) chain A residue 267 type sequence R description BINDING SITE FOR RESIDUE SO4 A 458 source : AC4 13) chain A residue 268 type sequence W description BINDING SITE FOR RESIDUE SO4 A 458 source : AC4 14) chain A residue 292 type sequence R description BINDING SITE FOR RESIDUE SO4 A 458 source : AC4 15) chain B residue 949 type sequence K description BINDING SITE FOR RESIDUE SO4 A 458 source : AC4 16) chain B residue 827 type sequence D description BINDING SITE FOR RESIDUE ZN B 950 source : AC5 17) chain B residue 831 type sequence H description BINDING SITE FOR RESIDUE ZN B 950 source : AC5 18) chain B residue 912 type sequence H description BINDING SITE FOR RESIDUE ZN B 950 source : AC5 19) chain B residue 551 type sequence D description BINDING SITE FOR RESIDUE ZN B 951 source : AC6 20) chain B residue 602 type sequence S description BINDING SITE FOR RESIDUE ZN B 951 source : AC6 21) chain B residue 827 type sequence D description BINDING SITE FOR RESIDUE ZN B 951 source : AC6 22) chain B residue 869 type sequence D description BINDING SITE FOR RESIDUE ZN B 951 source : AC6 23) chain B residue 870 type sequence H description BINDING SITE FOR RESIDUE ZN B 951 source : AC6 24) chain B residue 551 type sequence D description BINDING SITE FOR RESIDUE MG B 962 source : AC7 25) chain B residue 655 type sequence T description BINDING SITE FOR RESIDUE MG B 962 source : AC7 26) chain B residue 822 type sequence E description BINDING SITE FOR RESIDUE MG B 962 source : AC7 27) chain B residue 767 type sequence R description BINDING SITE FOR RESIDUE SO4 B 958 source : AC8 28) chain B residue 768 type sequence W description BINDING SITE FOR RESIDUE SO4 B 958 source : AC8 29) chain B residue 792 type sequence R description BINDING SITE FOR RESIDUE SO4 B 958 source : AC8 30) chain A residue 51 type catalytic sequence D description 44 source MCSA : MCSA1 31) chain A residue 369 type catalytic sequence D description 44 source MCSA : MCSA1 32) chain A residue 370 type catalytic sequence H description 44 source MCSA : MCSA1 33) chain A residue 412 type catalytic sequence H description 44 source MCSA : MCSA1 34) chain A residue 102 type catalytic sequence S description 44 source MCSA : MCSA1 35) chain A residue 153 type catalytic sequence D description 44 source MCSA : MCSA1 36) chain A residue 155 type catalytic sequence T description 44 source MCSA : MCSA1 37) chain A residue 166 type catalytic sequence R description 44 source MCSA : MCSA1 38) chain A residue 322 type catalytic sequence E description 44 source MCSA : MCSA1 39) chain A residue 327 type catalytic sequence D description 44 source MCSA : MCSA1 40) chain A residue 328 type catalytic sequence K description 44 source MCSA : MCSA1 41) chain A residue 331 type catalytic sequence H description 44 source MCSA : MCSA1 42) chain B residue 551 type catalytic sequence D description 44 source MCSA : MCSA2 43) chain B residue 869 type catalytic sequence D description 44 source MCSA : MCSA2 44) chain B residue 870 type catalytic sequence H description 44 source MCSA : MCSA2 45) chain B residue 912 type catalytic sequence H description 44 source MCSA : MCSA2 46) chain B residue 602 type catalytic sequence S description 44 source MCSA : MCSA2 47) chain B residue 653 type catalytic sequence D description 44 source MCSA : MCSA2 48) chain B residue 655 type catalytic sequence T description 44 source MCSA : MCSA2 49) chain B residue 666 type catalytic sequence R description 44 source MCSA : MCSA2 50) chain B residue 822 type catalytic sequence E description 44 source MCSA : MCSA2 51) chain B residue 827 type catalytic sequence D description 44 source MCSA : MCSA2 52) chain B residue 828 type catalytic sequence K description 44 source MCSA : MCSA2 53) chain B residue 831 type catalytic sequence H description 44 source MCSA : MCSA2 54) chain A residue 99-107 type prosite sequence VTDSAASAT description ALKALINE_PHOSPHATASE Alkaline phosphatase active site. VtDSAASAT source prosite : PS00123 55) chain A residue 102 type ACT_SITE sequence S description Phosphoserine intermediate source Swiss-Prot : SWS_FT_FI1 56) chain B residue 602 type ACT_SITE sequence S description Phosphoserine intermediate source Swiss-Prot : SWS_FT_FI1 57) chain A residue 51 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 58) chain B residue 551 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 59) chain B residue 653 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 60) chain B residue 655 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 61) chain B residue 822 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 62) chain B residue 827 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 63) chain B residue 831 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 64) chain B residue 869 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 65) chain B residue 870 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 66) chain B residue 912 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 67) chain A residue 153 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 68) chain A residue 155 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 69) chain A residue 322 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 70) chain A residue 327 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 71) chain A residue 331 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 72) chain A residue 369 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 73) chain A residue 370 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 74) chain A residue 412 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2

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