eF-site ID 1ed4-B PDB Code 1ed4 Chain B click to enlarge Title BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH IPITU (H4B FREE) Classification OXIDOREDUCTASE Compound NITRIC OXIDE SYNTHASE Source null (NOS3_BOVIN) Sequence B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAH EERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVG RIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRS AITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPA NVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLP PELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGL EFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLD TRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVS FMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVN YILSPAFRYQPDPW Description Functional site 1) chain B residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT B 2850 source : AC3 2) chain B residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT B 2850 source : AC3 3) chain B residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT B 2850 source : AC3 4) chain B residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT B 2860 source : AC4 5) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT B 2860 source : AC4 6) chain B residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT B 2860 source : AC4 7) chain B residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT B 2860 source : AC4 8) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 9) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 10) chain B residue 447 type sequence W description BINDING SITE FOR RESIDUE IPU B 1840 source : AC8 11) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE IPU B 1840 source : AC8 12) chain B residue 463 type sequence H description BINDING SITE FOR RESIDUE IPU B 1840 source : AC8 13) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 2500 source : BC1 14) chain B residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM B 2500 source : BC1 15) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 2500 source : BC1 16) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM B 2500 source : BC1 17) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 2500 source : BC1 18) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM B 2500 source : BC1 19) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 2500 source : BC1 20) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 2500 source : BC1 21) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 2500 source : BC1 22) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 2500 source : BC1 23) chain B residue 336 type sequence P description BINDING SITE FOR RESIDUE IPU B 2830 source : BC2 24) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE IPU B 2830 source : BC2 25) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE IPU B 2830 source : BC2 26) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE IPU B 2830 source : BC2 27) chain B residue 359 type sequence Y description BINDING SITE FOR RESIDUE IPU B 2830 source : BC2 28) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE IPU B 2830 source : BC2 29) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE IPU A 2840 source : BC3 30) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE IPU A 2840 source : BC3 31) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE IPU A 2840 source : BC3 32) chain B residue 83 type sequence Y description BINDING SITE FOR RESIDUE CAD B 2950 source : BC4 33) chain B residue 324 type sequence W description BINDING SITE FOR RESIDUE CAD B 2950 source : BC4 34) chain B residue 384 type sequence C description BINDING SITE FOR RESIDUE CAD B 2950 source : BC4 35) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE GOL B 1880 source : BC5 36) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE GOL A 2880 source : BC7 37) chain B residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL A 2880 source : BC7 38) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL A 2880 source : BC7 39) chain B residue 263 type sequence V description BINDING SITE FOR RESIDUE GOL B 2885 source : BC8 40) chain B residue 265 type sequence G description BINDING SITE FOR RESIDUE GOL B 2885 source : BC8 41) chain B residue 267 type sequence P description BINDING SITE FOR RESIDUE GOL B 2885 source : BC8 42) chain B residue 287 type sequence R description BINDING SITE FOR RESIDUE GOL B 2885 source : BC8 43) chain B residue 374 type sequence R description BINDING SITE FOR RESIDUE GOL B 2885 source : BC8 44) chain B residue 375 type sequence Y description BINDING SITE FOR RESIDUE GOL B 2885 source : BC8 45) chain B residue 154 type MOD_RES sequence E description Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 46) chain B residue 224 type BINDING sequence G description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 47) chain B residue 134 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 48) chain B residue 139 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 49) chain B residue 397 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 50) chain B residue 401 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 406 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 52) chain B residue 142 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 53) chain B residue 287 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 54) chain B residue 396 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2

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