eF-site ID 1ed4-A PDB Code 1ed4 Chain A click to enlarge Title BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH IPITU (H4B FREE) Classification OXIDOREDUCTASE Compound NITRIC OXIDE SYNTHASE Source null (NOS3_BOVIN) Sequence A:  GPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLV LPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQ AHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRC VGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNL RSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGD PANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFV LPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIG GLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMD LDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAAT VSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEM VNYILSPAFRYQPDPW Description Functional site 1) chain A residue 249 type sequence Q description BINDING SITE FOR RESIDUE ACT A 1850 source : AC1 2) chain A residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT A 1850 source : AC1 3) chain A residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT A 1850 source : AC1 4) chain A residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT A 1850 source : AC1 5) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT A 1860 source : AC2 6) chain A residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT A 1860 source : AC2 7) chain A residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT A 1860 source : AC2 8) chain A residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 9) chain A residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 10) chain A residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM A 1500 source : AC6 11) chain A residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM A 1500 source : AC6 12) chain A residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM A 1500 source : AC6 13) chain A residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM A 1500 source : AC6 14) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM A 1500 source : AC6 15) chain A residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM A 1500 source : AC6 16) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM A 1500 source : AC6 17) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM A 1500 source : AC6 18) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM A 1500 source : AC6 19) chain A residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM A 1500 source : AC6 20) chain A residue 336 type sequence P description BINDING SITE FOR RESIDUE IPU A 1830 source : AC7 21) chain A residue 338 type sequence V description BINDING SITE FOR RESIDUE IPU A 1830 source : AC7 22) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE IPU A 1830 source : AC7 23) chain A residue 356 type sequence S description BINDING SITE FOR RESIDUE IPU A 1830 source : AC7 24) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE IPU A 1830 source : AC7 25) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE IPU A 1830 source : AC7 26) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE IPU B 1840 source : AC8 27) chain A residue 448 type sequence A description BINDING SITE FOR RESIDUE IPU B 1840 source : AC8 28) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE IPU B 1840 source : AC8 29) chain A residue 324 type sequence W description BINDING SITE FOR RESIDUE CAD A 1950 source : AC9 30) chain A residue 384 type sequence C description BINDING SITE FOR RESIDUE CAD A 1950 source : AC9 31) chain A residue 447 type sequence W description BINDING SITE FOR RESIDUE IPU A 2840 source : BC3 32) chain A residue 462 type sequence F description BINDING SITE FOR RESIDUE IPU A 2840 source : BC3 33) chain A residue 463 type sequence H description BINDING SITE FOR RESIDUE IPU A 2840 source : BC3 34) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL B 1880 source : BC5 35) chain A residue 448 type sequence A description BINDING SITE FOR RESIDUE GOL B 1880 source : BC5 36) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL B 1880 source : BC5 37) chain A residue 263 type sequence V description BINDING SITE FOR RESIDUE GOL A 1885 source : BC6 38) chain A residue 265 type sequence G description BINDING SITE FOR RESIDUE GOL A 1885 source : BC6 39) chain A residue 267 type sequence P description BINDING SITE FOR RESIDUE GOL A 1885 source : BC6 40) chain A residue 287 type sequence R description BINDING SITE FOR RESIDUE GOL A 1885 source : BC6 41) chain A residue 375 type sequence Y description BINDING SITE FOR RESIDUE GOL A 1885 source : BC6 42) chain A residue 462 type sequence F description BINDING SITE FOR RESIDUE GOL A 2880 source : BC7 43) chain A residue 463 type sequence H description BINDING SITE FOR RESIDUE GOL A 2880 source : BC7 44) chain A residue 154 type MOD_RES sequence E description Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 45) chain A residue 224 type BINDING sequence G description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 46) chain A residue 185-192 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 47) chain A residue 134 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 139 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 49) chain A residue 142 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 287 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 51) chain A residue 396 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 52) chain A residue 397 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 53) chain A residue 401 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 54) chain A residue 406 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2

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