eF-site ID 1e8a-AB
PDB Code 1e8a
Chain A, B

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Title The three-dimensional structure of human S100A12
Classification ANTIFUNGAL PROTEIN
Compound S100A12
Source ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS;
Sequence A:  TKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKEL
ANTIKNIKDKAVIDEIFQGLDANQDEQVDFQEFISLVAIA
LKAAHYH
B:  TKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKEL
ANTIKNIKDKAVIDEIFQGLDANQDEQVDFQEFISLVAIA
LKAAHYHT
Description


Functional site
1) chain A
residue 18
type
sequence S
description BINDING SITE FOR RESIDUE CA A 1089
source : AC1
2) chain A
residue 21
type
sequence K
description BINDING SITE FOR RESIDUE CA A 1089
source : AC1
3) chain A
residue 23
type
sequence H
description BINDING SITE FOR RESIDUE CA A 1089
source : AC1
4) chain A
residue 26
type
sequence T
description BINDING SITE FOR RESIDUE CA A 1089
source : AC1
5) chain A
residue 31
type
sequence E
description BINDING SITE FOR RESIDUE CA A 1089
source : AC1
6) chain A
residue 61
type
sequence D
description BINDING SITE FOR RESIDUE CA A 1090
source : AC2
7) chain A
residue 63
type
sequence N
description BINDING SITE FOR RESIDUE CA A 1090
source : AC2
8) chain A
residue 65
type
sequence D
description BINDING SITE FOR RESIDUE CA A 1090
source : AC2
9) chain A
residue 67
type
sequence Q
description BINDING SITE FOR RESIDUE CA A 1090
source : AC2
10) chain A
residue 72
type
sequence E
description BINDING SITE FOR RESIDUE CA A 1090
source : AC2
11) chain B
residue 18
type
sequence S
description BINDING SITE FOR RESIDUE CA B 1089
source : AC3
12) chain B
residue 21
type
sequence K
description BINDING SITE FOR RESIDUE CA B 1089
source : AC3
13) chain B
residue 23
type
sequence H
description BINDING SITE FOR RESIDUE CA B 1089
source : AC3
14) chain B
residue 26
type
sequence T
description BINDING SITE FOR RESIDUE CA B 1089
source : AC3
15) chain B
residue 31
type
sequence E
description BINDING SITE FOR RESIDUE CA B 1089
source : AC3
16) chain B
residue 61
type
sequence D
description BINDING SITE FOR RESIDUE CA B 1090
source : AC4
17) chain B
residue 63
type
sequence N
description BINDING SITE FOR RESIDUE CA B 1090
source : AC4
18) chain B
residue 65
type
sequence D
description BINDING SITE FOR RESIDUE CA B 1090
source : AC4
19) chain B
residue 67
type
sequence Q
description BINDING SITE FOR RESIDUE CA B 1090
source : AC4
20) chain B
residue 72
type
sequence E
description BINDING SITE FOR RESIDUE CA B 1090
source : AC4
21) chain A
residue 56-77
type prosite
sequence IFQGLDANQDEQVDFQEFISLV
description S100_CABP S-100/ICaBP type calcium binding protein signature. IFqgLDanqDeqvDFqEFisLV
source prosite : PS00303
22) chain A
residue 26
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:19501594, ECO:0007744|PDB:2WC8, ECO:0007744|PDB:2WCB
source Swiss-Prot : SWS_FT_FI1
23) chain A
residue 86
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:19501594, ECO:0007744|PDB:2WC8, ECO:0007744|PDB:2WCB
source Swiss-Prot : SWS_FT_FI1
24) chain B
residue 16
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:19501594, ECO:0007744|PDB:2WC8, ECO:0007744|PDB:2WCB
source Swiss-Prot : SWS_FT_FI1
25) chain B
residue 26
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:19501594, ECO:0007744|PDB:2WC8, ECO:0007744|PDB:2WCB
source Swiss-Prot : SWS_FT_FI1
26) chain A
residue 16
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:19501594, ECO:0007744|PDB:2WC8, ECO:0007744|PDB:2WCB
source Swiss-Prot : SWS_FT_FI1
27) chain B
residue 86
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:19501594, ECO:0007744|PDB:2WC8, ECO:0007744|PDB:2WCB
source Swiss-Prot : SWS_FT_FI1
28) chain A
residue 22
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
29) chain A
residue 24
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
30) chain A
residue 27
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
31) chain A
residue 32
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
32) chain A
residue 62
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
33) chain A
residue 64
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
34) chain A
residue 66
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
35) chain A
residue 19
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
36) chain A
residue 73
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
37) chain B
residue 19
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
38) chain B
residue 22
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
39) chain B
residue 24
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
40) chain B
residue 27
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
41) chain B
residue 32
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
42) chain B
residue 62
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
43) chain B
residue 64
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
44) chain B
residue 66
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
45) chain B
residue 68
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
46) chain B
residue 73
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2
47) chain A
residue 68
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
source Swiss-Prot : SWS_FT_FI2

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