eF-site ID 1e82-E PDB Code 1e82 Chain E click to enlarge Title Endothiapepsin complex with renin inhibitor MERCK-KGAA-EMD59601 Classification HYDROLASE/HYDROLASE INHIBITOR Compound ENDOTHIAPEPSIN Source ORGANISM_SCIENTIFIC: ENDOTHIA PARASITICA; Sequence E:  STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSD LWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYG DGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDS TIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTAD LGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTST GYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVS GAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDF GPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGA TTPTLGFASK Description Functional site 1) chain E residue 12 type sequence D description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 2) chain E residue 30 type sequence D description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 3) chain E residue 32 type sequence D description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 4) chain E residue 34 type sequence G description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 5) chain E residue 75 type sequence Y description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 6) chain E residue 76 type sequence G description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 7) chain E residue 77 type sequence D description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 8) chain E residue 111 type sequence F description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 9) chain E residue 114 type sequence D description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 10) chain E residue 120 type sequence L description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 11) chain E residue 189 type sequence F description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 12) chain E residue 213 type sequence I description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 13) chain E residue 215 type sequence D description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 14) chain E residue 217 type sequence G description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 15) chain E residue 218 type sequence T description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 16) chain E residue 219 type sequence T description BINDING SITE FOR RESIDUE M90 E 400 source : AC1 17) chain E residue 32 type ACT_SITE sequence D description source Swiss-Prot : SWS_FT_FI1 18) chain E residue 194 type ACT_SITE sequence S description source Swiss-Prot : SWS_FT_FI1 19) chain E residue 29-40 type prosite sequence LDFDTGSSDLWV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWV source prosite : PS00141 20) chain E residue 212-223 type prosite sequence GIADTGTTLLYL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWV source prosite : PS00141

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