eF-site ID 1e7s-A PDB Code 1e7s Chain A click to enlarge Title GDP 4-keto-6-deoxy-D-mannose epimerase reductase K140R Classification EPIMERASE/REDUCTASE Compound GDP-FUCOSE SYNTHETASE Source (FCL_ECOLI) Sequence A:  KQRVFIAGHRGMVGSAIRRQLEQRGDVELVLRTRDELNLL DSRAVHDFFASERIDQVYLAAAKVGGIVANNTYPADFIYQ NMMIESNIIHAAHQNDVNKLLFLGSSCIYPKLAKQPMAES ELLQGTLEPTNEPYAIARIAGIKLCESYNRQYGRDYRSVM PTNLYGPHDNFHPSNSHVIPALLRRFHEATAQSAPDVVVW GSGTPMREFLHVDDMAAASIHVMELAHEVWLENTQPMLSH INVGTGVDCTIRELAQTIAKVVGYKGRVVFDASKPDGTPR KLLDVTRLHQLGWYHEISLEAGLASTYQWFLENQ Description Functional site 1) chain A residue 11 type sequence H description BINDING SITE FOR RESIDUE SO4 A1319 source : AC1 2) chain A residue 12 type sequence R description BINDING SITE FOR RESIDUE SO4 A1319 source : AC1 3) chain A residue 20 type sequence R description BINDING SITE FOR RESIDUE SO4 A1319 source : AC1 4) chain A residue 35 type sequence T description BINDING SITE FOR RESIDUE SO4 A1319 source : AC1 5) chain A residue 152 type sequence R description BINDING SITE FOR RESIDUE SO4 A1320 source : AC2 6) chain A residue 238 type sequence P description BINDING SITE FOR RESIDUE SO4 A1320 source : AC2 7) chain A residue 254 type sequence R description BINDING SITE FOR RESIDUE SO4 A1320 source : AC2 8) chain A residue 270 type sequence V description BINDING SITE FOR RESIDUE SO4 A1320 source : AC2 9) chain A residue 271 type sequence V description BINDING SITE FOR RESIDUE SO4 A1320 source : AC2 10) chain A residue 272 type sequence F description BINDING SITE FOR RESIDUE SO4 A1320 source : AC2 11) chain A residue 209 type sequence R description BINDING SITE FOR RESIDUE SO4 A1322 source : AC3 12) chain A residue 283 type sequence K description BINDING SITE FOR RESIDUE SO4 A1322 source : AC3 13) chain A residue 13 type sequence G description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 14) chain A residue 14 type sequence M description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 15) chain A residue 15 type sequence V description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 16) chain A residue 36 type sequence R description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 17) chain A residue 39 type sequence L description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 18) chain A residue 40 type sequence N description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 19) chain A residue 41 type sequence L description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 20) chain A residue 42 type sequence L description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 21) chain A residue 63 type sequence A description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 22) chain A residue 64 type sequence A description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 23) chain A residue 66 type sequence V description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 24) chain A residue 67 type sequence G description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 25) chain A residue 68 type sequence G description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 26) chain A residue 86 type sequence I description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 27) chain A residue 171 type sequence D description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 28) chain A residue 177 type sequence N description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 29) chain A residue 179 type sequence H description BINDING SITE FOR RESIDUE NAP A1317 source : AC4 30) chain A residue 67 type sequence G description BINDING SITE FOR RESIDUE UVW A1318 source : AC5 31) chain A residue 68 type sequence G description BINDING SITE FOR RESIDUE UVW A1318 source : AC5 32) chain A residue 69 type sequence I description BINDING SITE FOR RESIDUE UVW A1318 source : AC5 33) chain A residue 70 type sequence V description BINDING SITE FOR RESIDUE UVW A1318 source : AC5 34) chain A residue 71 type sequence A description BINDING SITE FOR RESIDUE UVW A1318 source : AC5 35) chain A residue 178 type sequence S description BINDING SITE FOR RESIDUE UVW A1318 source : AC5 36) chain A residue 262 type sequence K description BINDING SITE FOR RESIDUE UVW A1318 source : AC5 37) chain A residue 20 type sequence R description BINDING SITE FOR RESIDUE TRS A1321 source : AC6 38) chain A residue 21 type sequence R description BINDING SITE FOR RESIDUE TRS A1321 source : AC6 39) chain A residue 170 type sequence H description BINDING SITE FOR RESIDUE TRS A1321 source : AC6 40) chain A residue 311 type sequence W description BINDING SITE FOR RESIDUE TRS A1321 source : AC6 41) chain A residue 107 type catalytic sequence S description 227 source MCSA : MCSA1 42) chain A residue 108 type catalytic sequence S description 227 source MCSA : MCSA1 43) chain A residue 109 type catalytic sequence C description 227 source MCSA : MCSA1 44) chain A residue 136 type catalytic sequence Y description 227 source MCSA : MCSA1 45) chain A residue 140 type catalytic sequence R description 227 source MCSA : MCSA1 46) chain A residue 179 type catalytic sequence H description 227 source MCSA : MCSA1 47) chain A residue 107 type SITE sequence S description Important for catalytic activity source Swiss-Prot : SWS_FT_FI5 48) chain A residue 109 type SITE sequence C description Important for catalytic activity source Swiss-Prot : SWS_FT_FI5 49) chain A residue 140 type SITE sequence R description Lowers pKa of active site Tyr source Swiss-Prot : SWS_FT_FI6 50) chain A residue 187 type BINDING sequence R description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 51) chain A residue 202 type BINDING sequence W description BINDING => ECO:0000255|HAMAP-Rule:MF_00956 source Swiss-Prot : SWS_FT_FI4 52) chain A residue 209 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00956 source Swiss-Prot : SWS_FT_FI4 53) chain A residue 278 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00956 source Swiss-Prot : SWS_FT_FI4 54) chain A residue 136 type ACT_SITE sequence Y description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:11021971 source Swiss-Prot : SWS_FT_FI1 55) chain A residue 10 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9817848, ECO:0000269|PubMed:9862812 source Swiss-Prot : SWS_FT_FI2 56) chain A residue 36 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9817848, ECO:0000269|PubMed:9862812 source Swiss-Prot : SWS_FT_FI2 57) chain A residue 105 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9817848, ECO:0000269|PubMed:9862812 source Swiss-Prot : SWS_FT_FI2 58) chain A residue 140 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9817848, ECO:0000269|PubMed:9862812 source Swiss-Prot : SWS_FT_FI2 59) chain A residue 163 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9817848, ECO:0000269|PubMed:9862812 source Swiss-Prot : SWS_FT_FI2 60) chain A residue 179 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9817848, ECO:0000269|PubMed:9862812 source Swiss-Prot : SWS_FT_FI2

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