eF-site ID 1e74_19-A
PDB Code 1e74
Model 19
Chain A

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Title NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT R11E
Classification PEPTIDE TOXIN
Compound ALPHA-CONOTOXIN IM1(R11E)
Source Conus imperialis (Imperial cone) (CXA1_CONIM)
Sequence A:  GCCSDPRCAWECX
Description (1)  ALPHA-CONOTOXIN IM1(R11E)


Functional site

1) chain A
residue 5
type SITE
ligand
sequence D
description Important for binding to human alpha-7 nAChR. {ECO:0000305|PubMed:15609996}.
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 6
type SITE
ligand
sequence P
description Important for binding to human alpha-7 nAChR. {ECO:0000305|PubMed:15609996}.
source Swiss-Prot : SWS_FT_FI1

3) chain A
residue 7
type SITE
ligand
sequence R
description Important for binding to human alpha-7 nAChR. {ECO:0000305|PubMed:15609996}.
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 2-3
type binding
ligand NH2: AMINO GROUP
sequence CC
description AMINO GROUP binding site
source pdb_hetatom : NH2_1e74_A_13

5) chain A
residue 8-12
type binding
ligand NH2: AMINO GROUP
sequence CAWEC
description AMINO GROUP binding site
source pdb_hetatom : NH2_1e74_A_13

6) chain A
residue 1
type binding
ligand NH2: AMINO GROUP
sequence G
description AMINO GROUP binding site
source pdb_hetatom : NH2_1e74_A_13


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