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eF-site ID
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1e66-A |
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PDB Code
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1e66 |
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Chain
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A |
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click to enlarge
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Title
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STRUCTURE OF ACETYLCHOLINESTERASE COMPLEXED WITH (-)-HUPRINE X AT 2.1A RESOLUTION |
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Classification
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HYDROLASE |
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Compound
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ACETYLCHOLINESTERASE |
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Source
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ORGANISM_COMMON: PACIFIC ELECTRIC RAY; ORGANISM_SCIENTIFIC: TORPEDO CALIFORNICA; |
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Sequence
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A: |
SELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNM
RFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEM
WNPNREMSEDCLYLNIWVPSPRPKSTTVMVWIYGGGFYSG
SSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSQE
APGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGG
ASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRR
RAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEWNVLP
FDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGV
NKDEGSFFLLYGAPGFSKDSESKISREDFMSGVKLSVPHA
NDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHNVICP
LMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYE
IEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPN
EPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQMCVF
WNQFLPKLLNATA
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Description
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Functional site
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1)
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chain |
A |
| residue |
187-202 |
| type |
prosite |
| sequence |
FGGDPKTVTIFGESAG
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| description |
CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdpktVtIfGeSAG
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| source |
prosite : PS00122
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2)
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chain |
A |
| residue |
92-102 |
| type |
prosite |
| sequence |
EDCLYLNIWVP
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| description |
CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNIWvP
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| source |
prosite : PS00941
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3)
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chain |
A |
| residue |
200 |
| type |
ACT_SITE |
| sequence |
S
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| description |
Acyl-ester intermediate
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| source |
Swiss-Prot : SWS_FT_FI1
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4)
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chain |
A |
| residue |
327 |
| type |
ACT_SITE |
| sequence |
E
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| description |
Charge relay system
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| source |
Swiss-Prot : SWS_FT_FI2
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5)
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chain |
A |
| residue |
440 |
| type |
ACT_SITE |
| sequence |
H
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| description |
Charge relay system
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| source |
Swiss-Prot : SWS_FT_FI2
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6)
|
chain |
A |
| residue |
59 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558
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| source |
Swiss-Prot : SWS_FT_FI4
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7)
|
chain |
A |
| residue |
416 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558, ECO:0000269|PubMed:1678899
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| source |
Swiss-Prot : SWS_FT_FI5
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8)
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chain |
A |
| residue |
457 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299
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| source |
Swiss-Prot : SWS_FT_FI6
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9)
|
chain |
A |
| residue |
533 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299
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| source |
Swiss-Prot : SWS_FT_FI6
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