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eF-site ID
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1e3g-A |
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PDB Code
|
1e3g |
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Chain
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A |
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click to enlarge
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Title
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Human Androgen Receptor Ligand Binding in complex with the ligand metribolone (R1881) |
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Classification
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ANDROGEN RECEPTOR |
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Compound
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ANDROGEN RECEPTOR |
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Source
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(ANDR_HUMAN) |
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Sequence
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A: |
CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELG
ERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFA
MGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMR
HLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFD
ELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQP
IARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILS
GKVKPIYFHT
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Description
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Functional site
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1)
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chain |
A |
| residue |
704 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE R18 A1000
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| source |
: AC1
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2)
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chain |
A |
| residue |
705 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE R18 A1000
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| source |
: AC1
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3)
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chain |
A |
| residue |
711 |
| type |
|
| sequence |
Q
|
| description |
BINDING SITE FOR RESIDUE R18 A1000
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| source |
: AC1
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4)
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chain |
A |
| residue |
745 |
| type |
|
| sequence |
M
|
| description |
BINDING SITE FOR RESIDUE R18 A1000
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| source |
: AC1
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5)
|
chain |
A |
| residue |
749 |
| type |
|
| sequence |
M
|
| description |
BINDING SITE FOR RESIDUE R18 A1000
|
| source |
: AC1
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|
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6)
|
chain |
A |
| residue |
752 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE R18 A1000
|
| source |
: AC1
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|
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7)
|
chain |
A |
| residue |
877 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE R18 A1000
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| source |
: AC1
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8)
|
chain |
A |
| residue |
846 |
| type |
CROSSLNK |
| sequence |
R
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19345326
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| source |
Swiss-Prot : SWS_FT_FI6
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9)
|
chain |
A |
| residue |
848 |
| type |
CROSSLNK |
| sequence |
N
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19345326
|
| source |
Swiss-Prot : SWS_FT_FI6
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|
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10)
|
chain |
A |
| residue |
721 |
| type |
SITE |
| sequence |
A
|
| description |
Interaction with coactivator LXXL and FXXFY motifs => ECO:0000269|PubMed:25091737
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| source |
Swiss-Prot : SWS_FT_FI3
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11)
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chain |
A |
| residue |
898 |
| type |
SITE |
| sequence |
I
|
| description |
Interaction with coactivator FXXLF and FXXFY motifs => ECO:0000269|PubMed:25091737
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| source |
Swiss-Prot : SWS_FT_FI4
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12)
|
chain |
A |
| residue |
916 |
| type |
MOD_RES |
| sequence |
F
|
| description |
Phosphotyrosine; by CSK => ECO:0000269|PubMed:17045208
|
| source |
Swiss-Prot : SWS_FT_FI5
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|
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13)
|
chain |
A |
| residue |
706 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:16641486, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:25091737, ECO:0007744|PDB:1T5Z, ECO:0007744|PDB:1T63, ECO:0007744|PDB:1T65, ECO:0007744|PDB:1XJ7, ECO:0007744|PDB:2AM9, ECO:0007744|PDB:2AMA, ECO:0007744|PDB:2AMB, ECO:0007744|PDB:2PIO, ECO:0007744|PDB:2PIP, ECO:0007744|PDB:2PIR, ECO:0007744|PDB:2PIT, ECO:0007744|PDB:2PIU, ECO:0007744|PDB:2PIV, ECO:0007744|PDB:2PIW, ECO:0007744|PDB:2PIX, ECO:0007744|PDB:2PKL, ECO:0007744|PDB:2PNU, ECO:0007744|PDB:2Q7I, ECO:0007744|PDB:2Q7J, ECO:0007744|PDB:2Q7K, ECO:0007744|PDB:2Q7L, ECO:0007744|PDB:2YHD, ECO:0007744|PDB:2YLO, ECO:0007744|PDB:2YLP, ECO:0007744|PDB:2YLQ, ECO:0007744|PDB:3L3X, ECO:0007744|PDB:3L3Z, ECO:0007744|PDB:3ZQT, ECO:0007744|PDB:4HLW, ECO:0007744|PDB:4K7A, ECO:0007744|PDB:4OEA, ECO:0007744|PDB:4OED, ECO:0007744|PDB:4OEY, ECO:0007744|PDB:4OEZ, ECO:0007744|PDB:4OFR, ECO:0007744|PDB:4OFU, ECO:0007744|PDB:5JJM
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| source |
Swiss-Prot : SWS_FT_FI1
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14)
|
chain |
A |
| residue |
878 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:16641486, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:25091737, ECO:0007744|PDB:1T5Z, ECO:0007744|PDB:1T63, ECO:0007744|PDB:1T65, ECO:0007744|PDB:1XJ7, ECO:0007744|PDB:2AM9, ECO:0007744|PDB:2AMA, ECO:0007744|PDB:2PIO, ECO:0007744|PDB:2PIP, ECO:0007744|PDB:2PIQ, ECO:0007744|PDB:2PIR, ECO:0007744|PDB:2PIT, ECO:0007744|PDB:2PIU, ECO:0007744|PDB:2PIV, ECO:0007744|PDB:2PIW, ECO:0007744|PDB:2PIX, ECO:0007744|PDB:2PKL, ECO:0007744|PDB:2Q7I, ECO:0007744|PDB:2Q7J, ECO:0007744|PDB:2Q7K, ECO:0007744|PDB:2Q7L, ECO:0007744|PDB:2YHD, ECO:0007744|PDB:2YLO, ECO:0007744|PDB:2YLP, ECO:0007744|PDB:2YLQ, ECO:0007744|PDB:2Z4J, ECO:0007744|PDB:3L3X, ECO:0007744|PDB:3L3Z, ECO:0007744|PDB:3ZQT, ECO:0007744|PDB:4HLW, ECO:0007744|PDB:4K7A, ECO:0007744|PDB:4OEA, ECO:0007744|PDB:4OED, ECO:0007744|PDB:4OEY, ECO:0007744|PDB:4OEZ, ECO:0007744|PDB:4OFR, ECO:0007744|PDB:4OFU, ECO:0007744|PDB:5JJM
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| source |
Swiss-Prot : SWS_FT_FI2
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15)
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chain |
A |
| residue |
753 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:16641486, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:25091737, ECO:0007744|PDB:1T5Z, ECO:0007744|PDB:1T63, ECO:0007744|PDB:1T65, ECO:0007744|PDB:1XJ7, ECO:0007744|PDB:2AM9, ECO:0007744|PDB:2AMA, ECO:0007744|PDB:2PIO, ECO:0007744|PDB:2PIP, ECO:0007744|PDB:2PIQ, ECO:0007744|PDB:2PIR, ECO:0007744|PDB:2PIT, ECO:0007744|PDB:2PIU, ECO:0007744|PDB:2PIV, ECO:0007744|PDB:2PIW, ECO:0007744|PDB:2PIX, ECO:0007744|PDB:2PKL, ECO:0007744|PDB:2Q7I, ECO:0007744|PDB:2Q7J, ECO:0007744|PDB:2Q7K, ECO:0007744|PDB:2Q7L, ECO:0007744|PDB:2YHD, ECO:0007744|PDB:2YLO, ECO:0007744|PDB:2YLP, ECO:0007744|PDB:2YLQ, ECO:0007744|PDB:2Z4J, ECO:0007744|PDB:3L3X, ECO:0007744|PDB:3L3Z, ECO:0007744|PDB:3ZQT, ECO:0007744|PDB:4HLW, ECO:0007744|PDB:4K7A, ECO:0007744|PDB:4OEA, ECO:0007744|PDB:4OED, ECO:0007744|PDB:4OEY, ECO:0007744|PDB:4OEZ, ECO:0007744|PDB:4OFR, ECO:0007744|PDB:4OFU, ECO:0007744|PDB:5JJM
|
| source |
Swiss-Prot : SWS_FT_FI2
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