eF-site ID 1e3a-AB PDB Code 1e3a Chain A, B click to enlarge Title A slow processing precursor penicillin acylase from Escherichia coli Classification ANTIBIOTIC RESISTANCE Compound PENICILLIN AMIDASE ALPHA SUBUNIT Source (PAC_ECOLI) Sequence A:  SSSEIKIVRDEYGMPHIYANDTWHLFYGYGYVVAQDRLFQ MEMARRSTQGTVAEVLGKDFVKFDKDIRRNYWPDAIRAQI AALSPEDMSILQGYADGMNAWIDKVNTNPETLLPKQFNTF GFTPKRWEPFDVAMIFVGTMANRFSDSTSEIDNLALLTAL KDKYGVSQGMAVFNQLKWLVNPSAPTTIAVQESNYPLKFN QQNSQTAALLPRYDLPAPMLDRPAKGADGALLALAAGKNR ETIAAQFAQGGANGLAGY B:  PTGSNMWVIGKSKAQDAKAIMVNGPQFGWYAPAYTYGIGL HGAGYDVTGNTPFAYPGLVFGHNGVISWGSTAGFGDDVDI FAERLSAEKPGYYLHNGKWVKMLSREETITVKNGQAETFT VWRTVHGNILQTDQTTQTAYAKSRAWDGKEVASLLAWTHQ MKAKNWQEWTQQAAKQALTINWYYADVNGNIGYVHTGAYP DRQSGHDPRLPVPGTGKWDWKGLLPFEMNPKVYNPQSGYI ANWNNSPQKDYPASDLFAFLWGGADRVTEIDRLLEQKPRL TADQAWDVIRQTSRQDLNLRLFLPTLQAATSGLTQSDPRR QLVETLTRWDGINLLNDDGKTWQQPGSAILNVWLTSMLKR TVVAAVPMPFDKWYSASGYETTQDGPTGSLNISVGAKILY EAVQGDKSPIPQAVDLFAGKPQQEVVLAALEDTWETLSKR YGNNVSNWKTPAMALTFRANNFFGVPQAAAEETRHQAEYQ NRGTENDMIVFSPTTSDRPVLAWDVVAPGQSGFIAPDGTV DKHYEDQLKMYENFGRKSLWLTKQDVEAHKESQEVLHVQR Description Functional site 1) chain A residue 187 type sequence P description BINDING SITE FOR RESIDUE EDO B 903 source : AC1 2) chain A residue 188 type sequence T description BINDING SITE FOR RESIDUE EDO B 903 source : AC1 3) chain B residue 501 type sequence A description BINDING SITE FOR RESIDUE EDO B 903 source : AC1 4) chain B residue 531 type sequence D description BINDING SITE FOR RESIDUE EDO B 903 source : AC1 5) chain B residue 264 type sequence S description BINDING SITE FOR RESIDUE EDO B 904 source : AC2 6) chain B residue 330 type sequence S description BINDING SITE FOR RESIDUE EDO B 904 source : AC2 7) chain B residue 331 type sequence T description BINDING SITE FOR RESIDUE EDO B 904 source : AC2 8) chain B residue 332 type sequence A description BINDING SITE FOR RESIDUE EDO B 904 source : AC2 9) chain B residue 519 type sequence F description BINDING SITE FOR RESIDUE EDO B 905 source : AC3 10) chain B residue 520 type sequence L description BINDING SITE FOR RESIDUE EDO B 905 source : AC3 11) chain B residue 651 type sequence N description BINDING SITE FOR RESIDUE EDO B 905 source : AC3 12) chain B residue 657 type sequence K description BINDING SITE FOR RESIDUE EDO B 905 source : AC3 13) chain A residue 152 type sequence E description BINDING SITE FOR RESIDUE CA B 901 source : AC4 14) chain B residue 336 type sequence D description BINDING SITE FOR RESIDUE CA B 901 source : AC4 15) chain B residue 338 type sequence V description BINDING SITE FOR RESIDUE CA B 901 source : AC4 16) chain B residue 339 type sequence D description BINDING SITE FOR RESIDUE CA B 901 source : AC4 17) chain B residue 468 type sequence P description BINDING SITE FOR RESIDUE CA B 901 source : AC4 18) chain B residue 515 type sequence D description BINDING SITE FOR RESIDUE CA B 901 source : AC4 19) chain A residue 254 type sequence A description BINDING SITE FOR RESIDUE CL B 902 source : AC5 20) chain B residue 654 type sequence V description BINDING SITE FOR RESIDUE CL B 902 source : AC5 21) chain B residue 264 type catalytic sequence S description 841 source MCSA : MCSA1 22) chain B residue 332 type catalytic sequence A description 841 source MCSA : MCSA1 23) chain B residue 504 type catalytic sequence N description 841 source MCSA : MCSA1 24) chain B residue 264 type ACT_SITE sequence S description Nucleophile source Swiss-Prot : SWS_FT_FI1 25) chain B residue 336 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 26) chain B residue 338 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 27) chain B residue 339 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 28) chain B residue 468 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 29) chain B residue 515 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2

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