|
|
eF-site ID
|
1e1h-D |
|
PDB Code
|
1e1h |
|
Chain
|
D |
|
click to enlarge
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Title
|
Crystal Structure of recombinant Botulinum Neurotoxin Type A Light Chain, self-inhibiting Zn endopeptidase. |
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Classification
|
HYDROLASE |
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Compound
|
BOTULINUM NEUROTOXIN TYPE A LIGHT CHAIN |
|
Source
|
(1E1H) |
|
|
Sequence
|
D: |
YEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKF
KDVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGK
FSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINRKTYLNFD
KAVFRINIVPDENYTIKDGFNLKANLSTNFNGQNTEINSR
NFTRL
|
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Description
|
|
Functional site
|
|
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1)
|
chain |
D |
| residue |
261 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE ZN C 502
|
| source |
: AC2
|
|
|
2)
|
chain |
D |
| residue |
261 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:15107500, ECO:0000269|PubMed:16846233, ECO:0007744|PDB:2G7P, ECO:0007744|PDB:2G7Q
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
D |
| residue |
365 |
| type |
SITE |
| sequence |
Y
|
| description |
Transition state stabilizer => ECO:0000305|PubMed:16846233
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|