eF-site ID 1e1h-ABCD PDB Code 1e1h Chain A, B, C, D click to enlarge Title Crystal Structure of recombinant Botulinum Neurotoxin Type A Light Chain, self-inhibiting Zn endopeptidase. Classification HYDROLASE Compound BOTULINUM NEUROTOXIN TYPE A LIGHT CHAIN Source (1E1H) Sequence A:  MAYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPE RDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNY LKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTEL KVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKS FGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLGAGKFAT DPAVTLAHELIHAEHRLYGIAINPNRVFKVNTNAY B:  EMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFK DVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGKF SVDKLKFDKLYKMLTEIYTEDNFVNFFKVINRKTYLNFDK AVFRINIVPDENYTIKDGFNLKANLSTNFNGQNTEINSRN FTRL C:  MAYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPE RDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNY LKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTEL KVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKS FGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLGAGKFAT DPAVTLAHELIHAEHRLYGIAINPNRVFKVNTNAY D:  YEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKF KDVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGK FSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINRKTYLNFD KAVFRINIVPDENYTIKDGFNLKANLSTNFNGQNTEINSR NFTRL Description Functional site 1) chain A residue 222 type sequence H description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 2) chain A residue 226 type sequence H description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 3) chain B residue 261 type sequence E description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 4) chain C residue 249 type sequence Y description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 5) chain A residue 249 type sequence Y description BINDING SITE FOR RESIDUE ZN C 502 source : AC2 6) chain C residue 222 type sequence H description BINDING SITE FOR RESIDUE ZN C 502 source : AC2 7) chain C residue 226 type sequence H description BINDING SITE FOR RESIDUE ZN C 502 source : AC2 8) chain D residue 261 type sequence E description BINDING SITE FOR RESIDUE ZN C 502 source : AC2 9) chain B residue 261 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15107500, ECO:0000269|PubMed:16846233, ECO:0007744|PDB:2G7P, ECO:0007744|PDB:2G7Q source Swiss-Prot : SWS_FT_FI1 10) chain D residue 261 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15107500, ECO:0000269|PubMed:16846233, ECO:0007744|PDB:2G7P, ECO:0007744|PDB:2G7Q source Swiss-Prot : SWS_FT_FI1 11) chain C residue 222 type SITE sequence H description Transition state stabilizer => ECO:0000305|PubMed:16846233 source Swiss-Prot : SWS_FT_FI2 12) chain C residue 226 type SITE sequence H description Transition state stabilizer => ECO:0000305|PubMed:16846233 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 365 type SITE sequence Y description Transition state stabilizer => ECO:0000305|PubMed:16846233 source Swiss-Prot : SWS_FT_FI2 14) chain D residue 365 type SITE sequence Y description Transition state stabilizer => ECO:0000305|PubMed:16846233 source Swiss-Prot : SWS_FT_FI2

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