eF-site ID 1dyh-B PDB Code 1dyh Chain B click to enlarge Title ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS Classification OXIDOREDUCTASE Compound DIHYDROFOLATE REDUCTASE Source Escherichia coli (strain K12) (DYR_ECOLI) Sequence B:  MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Description Functional site 1) chain B residue 43 type sequence G description BINDING SITE FOR RESIDUE CL B 405 source : AC2 2) chain B residue 45 type sequence H description BINDING SITE FOR RESIDUE CL B 405 source : AC2 3) chain B residue 46 type sequence T description BINDING SITE FOR RESIDUE CL B 405 source : AC2 4) chain B residue 96 type sequence G description BINDING SITE FOR RESIDUE CL B 405 source : AC2 5) chain B residue 135 type sequence S description BINDING SITE FOR RESIDUE CA B 420 source : AC3 6) chain B residue 5 type sequence I description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 7) chain B residue 6 type sequence A description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 8) chain B residue 7 type sequence A description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 9) chain B residue 27 type sequence D description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 10) chain B residue 28 type sequence L description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 11) chain B residue 31 type sequence F description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 12) chain B residue 32 type sequence K description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 13) chain B residue 50 type sequence I description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 14) chain B residue 52 type sequence R description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 15) chain B residue 57 type sequence R description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 16) chain B residue 94 type sequence I description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 17) chain B residue 100 type sequence Y description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 18) chain B residue 113 type sequence T description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 19) chain B residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 27 type BINDING sequence D description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2

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