eF-site ID 1dyh-AB PDB Code 1dyh Chain A, B click to enlarge Title ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS Classification OXIDOREDUCTASE Compound DIHYDROFOLATE REDUCTASE Source Escherichia coli (strain K12) (DYR_ECOLI) Sequence A:  MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR B:  MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Description Functional site 1) chain A residue 43 type sequence G description BINDING SITE FOR RESIDUE CL A 401 source : AC1 2) chain A residue 45 type sequence H description BINDING SITE FOR RESIDUE CL A 401 source : AC1 3) chain A residue 46 type sequence T description BINDING SITE FOR RESIDUE CL A 401 source : AC1 4) chain A residue 96 type sequence G description BINDING SITE FOR RESIDUE CL A 401 source : AC1 5) chain B residue 43 type sequence G description BINDING SITE FOR RESIDUE CL B 405 source : AC2 6) chain B residue 45 type sequence H description BINDING SITE FOR RESIDUE CL B 405 source : AC2 7) chain B residue 46 type sequence T description BINDING SITE FOR RESIDUE CL B 405 source : AC2 8) chain B residue 96 type sequence G description BINDING SITE FOR RESIDUE CL B 405 source : AC2 9) chain B residue 135 type sequence S description BINDING SITE FOR RESIDUE CA B 420 source : AC3 10) chain A residue 5 type sequence I description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 11) chain A residue 6 type sequence A description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 12) chain A residue 7 type sequence A description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 13) chain A residue 27 type sequence D description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 14) chain A residue 28 type sequence L description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 15) chain A residue 31 type sequence F description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 16) chain A residue 46 type sequence T description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 17) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 18) chain A residue 52 type sequence R description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 19) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 20) chain A residue 94 type sequence I description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 21) chain A residue 113 type sequence T description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 22) chain B residue 5 type sequence I description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 23) chain B residue 6 type sequence A description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 24) chain B residue 7 type sequence A description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 25) chain B residue 27 type sequence D description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 26) chain B residue 28 type sequence L description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 27) chain B residue 31 type sequence F description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 28) chain B residue 32 type sequence K description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 29) chain B residue 50 type sequence I description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 30) chain B residue 52 type sequence R description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 31) chain B residue 57 type sequence R description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 32) chain B residue 94 type sequence I description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 33) chain B residue 100 type sequence Y description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 34) chain B residue 113 type sequence T description BINDING SITE FOR RESIDUE DZF B 161 source : AC5 35) chain A residue 13-35 type prosite sequence VIGMENAMPWNLPADLAWFKRNT description DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT source prosite : PS00075 36) chain A residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 27 type BINDING sequence D description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 27 type BINDING sequence D description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 45) chain B residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 47) chain B residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 48) chain B residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 49) chain B residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 51) chain A residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 52) chain A residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 53) chain A residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 54) chain A residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 55) chain B residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 56) chain B residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links