eF-site ID 1dyh-A PDB Code 1dyh Chain A click to enlarge Title ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS Classification OXIDOREDUCTASE Compound DIHYDROFOLATE REDUCTASE Source Escherichia coli (strain K12) (DYR_ECOLI) Sequence A:  MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Description Functional site 1) chain A residue 43 type sequence G description BINDING SITE FOR RESIDUE CL A 401 source : AC1 2) chain A residue 45 type sequence H description BINDING SITE FOR RESIDUE CL A 401 source : AC1 3) chain A residue 46 type sequence T description BINDING SITE FOR RESIDUE CL A 401 source : AC1 4) chain A residue 96 type sequence G description BINDING SITE FOR RESIDUE CL A 401 source : AC1 5) chain A residue 5 type sequence I description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 6) chain A residue 6 type sequence A description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 7) chain A residue 7 type sequence A description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 8) chain A residue 27 type sequence D description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 9) chain A residue 28 type sequence L description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 10) chain A residue 31 type sequence F description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 11) chain A residue 46 type sequence T description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 12) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 13) chain A residue 52 type sequence R description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 14) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 15) chain A residue 94 type sequence I description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 16) chain A residue 113 type sequence T description BINDING SITE FOR RESIDUE DZF A 161 source : AC4 17) chain A residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 27 type BINDING sequence D description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 13-35 type prosite sequence VIGMENAMPWNLPADLAWFKRNT description DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT source prosite : PS00075

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