eF-site ID 1dww-B PDB Code 1dww Chain B click to enlarge Title MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-hydroxyarginine and dihydrobiopterin Classification OXIDOREDUCTASE/TRANSFERASE Compound NITRIC OXIDE SYNTHASE Source Mus musculus (Mouse) (NOS2_MOUSE) Sequence B:  QYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNP KSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEH LARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIG RIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRS AITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAA TLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIP PDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGL EFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLE THTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASES FMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLN YVLSPFYYYQIEPWKTHIWQ Description (1)  NITRIC OXIDE SYNTHASE (E.C.1.14.13.39) Functional site 1) chain B residue 104 type sequence C description BINDING SITE FOR RESIDUE ZN B 903 source : AC6 2) chain B residue 104 type sequence C description BINDING SITE FOR RESIDUE ZN B 903 source : AC6 3) chain B residue 109 type sequence C description BINDING SITE FOR RESIDUE ZN B 903 source : AC6 4) chain B residue 109 type sequence C description BINDING SITE FOR RESIDUE ZN B 903 source : AC6 5) chain B residue 176 type sequence T description BINDING SITE FOR RESIDUE SO4 B 904 source : AC7 6) chain B residue 177 type sequence L description BINDING SITE FOR RESIDUE SO4 B 904 source : AC7 7) chain B residue 94 type sequence L description BINDING SITE FOR RESIDUE SO4 B 905 source : AC8 8) chain B residue 97 type sequence K description BINDING SITE FOR RESIDUE SO4 B 905 source : AC8 9) chain B residue 143 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 905 source : AC8 10) chain B residue 448 type sequence R description BINDING SITE FOR RESIDUE SO4 B 905 source : AC8 11) chain B residue 80 type sequence R description BINDING SITE FOR RESIDUE SO4 B 906 source : AC9 12) chain B residue 82 type sequence K description BINDING SITE FOR RESIDUE SO4 B 906 source : AC9 13) chain B residue 89 type sequence I description BINDING SITE FOR RESIDUE SO4 B 906 source : AC9 14) chain B residue 80 type sequence R description BINDING SITE FOR RESIDUE SO4 B 907 source : BC1 15) chain B residue 89 type sequence I description BINDING SITE FOR RESIDUE SO4 B 907 source : BC1 16) chain B residue 91 type sequence H description BINDING SITE FOR RESIDUE SO4 B 907 source : BC1 17) chain B residue 188 type sequence W description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 18) chain B residue 193 type sequence R description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 19) chain B residue 194 type sequence C description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 20) chain B residue 236 type sequence S description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 21) chain B residue 363 type sequence F description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 22) chain B residue 364 type sequence N description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 23) chain B residue 365 type sequence G description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 24) chain B residue 366 type sequence W description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 25) chain B residue 371 type sequence E description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 26) chain B residue 457 type sequence W description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 27) chain B residue 483 type sequence Y description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 28) chain B residue 485 type sequence Y description BINDING SITE FOR RESIDUE HEM B 901 source : BC5 29) chain B residue 112 type sequence S description BINDING SITE FOR RESIDUE H2B B 902 source : BC6 30) chain B residue 375 type sequence R description BINDING SITE FOR RESIDUE H2B B 902 source : BC6 31) chain B residue 455 type sequence W description BINDING SITE FOR RESIDUE H2B B 902 source : BC6 32) chain B residue 456 type sequence I description BINDING SITE FOR RESIDUE H2B B 902 source : BC6 33) chain B residue 457 type sequence W description BINDING SITE FOR RESIDUE H2B B 902 source : BC6 34) chain B residue 470 type sequence F description BINDING SITE FOR RESIDUE H2B B 902 source : BC6 35) chain B residue 471 type sequence H description BINDING SITE FOR RESIDUE H2B B 902 source : BC6 36) chain B residue 473 type sequence E description BINDING SITE FOR RESIDUE H2B B 902 source : BC6 37) chain B residue 257 type sequence Q description BINDING SITE FOR RESIDUE HAR B 909 source : BC7 38) chain B residue 341 type sequence Y description BINDING SITE FOR RESIDUE HAR B 909 source : BC7 39) chain B residue 344 type sequence P description BINDING SITE FOR RESIDUE HAR B 909 source : BC7 40) chain B residue 365 type sequence G description BINDING SITE FOR RESIDUE HAR B 909 source : BC7 41) chain B residue 366 type sequence W description BINDING SITE FOR RESIDUE HAR B 909 source : BC7 42) chain B residue 367 type sequence Y description BINDING SITE FOR RESIDUE HAR B 909 source : BC7 43) chain B residue 371 type sequence E description BINDING SITE FOR RESIDUE HAR B 909 source : BC7 44) chain B residue 376 type sequence D description BINDING SITE FOR RESIDUE HAR B 909 source : BC7 45) chain B residue 104 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1N2N source Swiss-Prot : SWS_FT_FI1 46) chain B residue 109 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1N2N source Swiss-Prot : SWS_FT_FI1 47) chain B residue 257 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 48) chain B residue 366 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 49) chain B residue 367 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 50) chain B residue 371 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 51) chain B residue 375 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI5 52) chain B residue 456 type BINDING sequence I description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N source Swiss-Prot : SWS_FT_FI6 53) chain B residue 457 type BINDING sequence W description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI7 54) chain B residue 470 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI8 55) chain B residue 485 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI9 56) chain B residue 194 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9334294, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOC, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1NOS, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:2NOS, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI3 57) chain B residue 112 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD source Swiss-Prot : SWS_FT_FI2

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