eF-site ID 1dww-A
PDB Code 1dww
Chain A

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Title MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-hydroxyarginine and dihydrobiopterin
Classification OXIDOREDUCTASE/TRANSFERASE
Compound NITRIC OXIDE SYNTHASE
Source Mus musculus (Mouse) (NOS2_MOUSE)
Sequence A:  QYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNP
KSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEH
LARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIG
RIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRS
AITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAA
TLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIP
PDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGL
EFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLE
THTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASES
FMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLN
YVLSPFYYYQIEPWKTHIWQ
Description


Functional site
1) chain A
residue 104
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 903
source : AC1
2) chain A
residue 104
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 903
source : AC1
3) chain A
residue 109
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 903
source : AC1
4) chain A
residue 109
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 903
source : AC1
5) chain A
residue 80
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 904
source : AC2
6) chain A
residue 91
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 904
source : AC2
7) chain A
residue 80
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 905
source : AC3
8) chain A
residue 82
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 905
source : AC3
9) chain A
residue 89
type
sequence I
description BINDING SITE FOR RESIDUE SO4 A 905
source : AC3
10) chain A
residue 177
type
sequence L
description BINDING SITE FOR RESIDUE SO4 A 906
source : AC4
11) chain A
residue 97
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 907
source : AC5
12) chain A
residue 143
type
sequence Q
description BINDING SITE FOR RESIDUE SO4 A 907
source : AC5
13) chain A
residue 448
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 907
source : AC5
14) chain A
residue 188
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 901
source : BC2
15) chain A
residue 193
type
sequence R
description BINDING SITE FOR RESIDUE HEM A 901
source : BC2
16) chain A
residue 194
type
sequence C
description BINDING SITE FOR RESIDUE HEM A 901
source : BC2
17) chain A
residue 236
type
sequence S
description BINDING SITE FOR RESIDUE HEM A 901
source : BC2
18) chain A
residue 363
type
sequence F
description BINDING SITE FOR RESIDUE HEM A 901
source : BC2
19) chain A
residue 364
type
sequence N
description BINDING SITE FOR RESIDUE HEM A 901
source : BC2
20) chain A
residue 365
type
sequence G
description BINDING SITE FOR RESIDUE HEM A 901
source : BC2
21) chain A
residue 366
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 901
source : BC2
22) chain A
residue 371
type
sequence E
description BINDING SITE FOR RESIDUE HEM A 901
source : BC2
23) chain A
residue 457
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 901
source : BC2
24) chain A
residue 485
type
sequence Y
description BINDING SITE FOR RESIDUE HEM A 901
source : BC2
25) chain A
residue 112
type
sequence S
description BINDING SITE FOR RESIDUE H2B A 902
source : BC3
26) chain A
residue 375
type
sequence R
description BINDING SITE FOR RESIDUE H2B A 902
source : BC3
27) chain A
residue 456
type
sequence I
description BINDING SITE FOR RESIDUE H2B A 902
source : BC3
28) chain A
residue 457
type
sequence W
description BINDING SITE FOR RESIDUE H2B A 902
source : BC3
29) chain A
residue 470
type
sequence F
description BINDING SITE FOR RESIDUE H2B A 902
source : BC3
30) chain A
residue 471
type
sequence H
description BINDING SITE FOR RESIDUE H2B A 902
source : BC3
31) chain A
residue 257
type
sequence Q
description BINDING SITE FOR RESIDUE HAR A 909
source : BC4
32) chain A
residue 341
type
sequence Y
description BINDING SITE FOR RESIDUE HAR A 909
source : BC4
33) chain A
residue 344
type
sequence P
description BINDING SITE FOR RESIDUE HAR A 909
source : BC4
34) chain A
residue 365
type
sequence G
description BINDING SITE FOR RESIDUE HAR A 909
source : BC4
35) chain A
residue 366
type
sequence W
description BINDING SITE FOR RESIDUE HAR A 909
source : BC4
36) chain A
residue 367
type
sequence Y
description BINDING SITE FOR RESIDUE HAR A 909
source : BC4
37) chain A
residue 371
type
sequence E
description BINDING SITE FOR RESIDUE HAR A 909
source : BC4
38) chain A
residue 376
type
sequence D
description BINDING SITE FOR RESIDUE HAR A 909
source : BC4
39) chain A
residue 193-200
type prosite
sequence RCIGRIQW
description NOS Nitric oxide synthase (NOS) signature. RCIGRIqW
source prosite : PS60001
40) chain A
residue 104
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1N2N
source Swiss-Prot : SWS_FT_FI1
41) chain A
residue 109
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1N2N
source Swiss-Prot : SWS_FT_FI1
42) chain A
residue 112
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
source Swiss-Prot : SWS_FT_FI2
43) chain A
residue 194
type BINDING
sequence C
description axial binding residue => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9334294, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOC, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1NOS, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:2NOS, ECO:0007744|PDB:3NOD
source Swiss-Prot : SWS_FT_FI3
44) chain A
residue 257
type BINDING
sequence Q
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI4
45) chain A
residue 366
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI4
46) chain A
residue 367
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI4
47) chain A
residue 371
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P29474
source Swiss-Prot : SWS_FT_FI4
48) chain A
residue 375
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:3NOD
source Swiss-Prot : SWS_FT_FI5
49) chain A
residue 456
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N
source Swiss-Prot : SWS_FT_FI6
50) chain A
residue 457
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
source Swiss-Prot : SWS_FT_FI7
51) chain A
residue 470
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
source Swiss-Prot : SWS_FT_FI8
52) chain A
residue 485
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
source Swiss-Prot : SWS_FT_FI9

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