eF-site ID 1dwo-A PDB Code 1dwo Chain A click to enlarge Title Crystal Structure of Hydroxynitrile Lyase from Manihot esculenta in Complex with Substrates Acetone and Chloroacetone:Implications for the Mechanism of Cyanogenesis Classification HYDROXYNITRILE LYASE Compound HYDROXYNITRILE LYASE Source (HNL_MANES) Sequence A:  PISKMVTAHFVLIHTICHGAWIWHKLKPALERAGHKVTAL DMAASGIDPRQIEQINSFDEYSEPLLTFLEKLPQGEKVII VGESCAGLNIAIAADRYVDKIAAGVFHNSLLPDTVHSPSY TVEKLLESFPDWRDTEYFTFTNITGETITTMKLGFVLLRE NLFTKCTDGEYELAKMVMRKGSLFQNVLAQRPKFTEKGYG SIKKVYIWTDQDKIFLPDFQRWQIANYKPDKVYQVQGGDH KLQLTKTEEVAHILQEVADAYA Description (1)  HYDROXYNITRILE LYASE (E.C.4.2.1.37) Functional site 1) chain A residue 11 type sequence T description BINDING SITE FOR RESIDUE ACN S 259 source : AC1 2) chain A residue 12 type sequence I description BINDING SITE FOR RESIDUE ACN S 259 source : AC1 3) chain A residue 80 type sequence S description BINDING SITE FOR RESIDUE ACN S 259 source : AC1 4) chain A residue 81 type sequence C description BINDING SITE FOR RESIDUE ACN S 259 source : AC1 5) chain A residue 149 type sequence L description BINDING SITE FOR RESIDUE ACN S 259 source : AC1 6) chain A residue 81 type ACT_SITE sequence C description Proton donor/acceptor => ECO:0000305|PubMed:11173464, ECO:0000305|PubMed:11316882 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 237 type ACT_SITE sequence K description Proton donor/acceptor => ECO:0000305|PubMed:11173464, ECO:0000305|PubMed:11316882 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 12 type BINDING sequence I description BINDING => ECO:0000269|PubMed:11173464, ECO:0007744|PDB:1DWO source Swiss-Prot : SWS_FT_FI2 9) chain A residue 81 type BINDING sequence C description BINDING => ECO:0000269|PubMed:11173464, ECO:0007744|PDB:1DWO source Swiss-Prot : SWS_FT_FI2 10) chain A residue 82 type BINDING sequence A description BINDING => ECO:0000269|PubMed:11173464, ECO:0007744|PDB:1DWO source Swiss-Prot : SWS_FT_FI2 11) chain A residue 209 type SITE sequence K description Increases basicity of active site His => ECO:0000305|PubMed:11316882 source Swiss-Prot : SWS_FT_FI3

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