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Title
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Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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ALPHA-THROMBIN light chain |
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Source
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ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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L: |
EADCGLRPLFEKKSLEDKTERELLESYI
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Description
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(1) |
ALPHA-THROMBIN (E.C.3.4.21.5) COMPLEX WITH (DES-AMINO ASP 55) HIRUDIN (RESIDUES 55 - 65) AND D-PHE-PRO-ARG-CHLOROMETHYLKETONE (PPACK) WITH CHLOROMETHYLKETONE REPLACED BY A METHYLENE GROUP
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