eF-site ID 1dvi-AB PDB Code 1dvi Chain A, B click to enlarge Title CALPAIN DOMAIN VI WITH CALCIUM BOUND Classification CALCIUM-DEPENDENT PROTEASE Compound CALPAIN Source Rattus norvegicus (Rat) (CPNS1_RAT) Sequence A:  EEERQFRKLFVQLAGDDMEVSATELMNILNKVVTRHPDLK TDGFGIDTSRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQ GIYKRFDTDRSGTIGSNELPGAFEAAGFHLNQHIYSMIIR RYSDETGNMDFDNFISCLVRLDAMFRAFRSLDKNGTGQIQ VNIQEWLQLTMYS B:  EEERQFRKLFVQLAGDDMEVSATELMNILNKVVTRHPDLK TDGFGIDTSRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQ GIYKRFDTDRSGTIGSNELPGAFEAAGFHLNQHIYSMIIR RYSDETGNMDFDNFISCLVRLDAMFRAFRSLDKNGTGQIQ VNIQEWLQLTMYS Description Functional site 1) chain A residue 111 type sequence A description BINDING SITE FOR RESIDUE CA A 271 source : AC1 2) chain A residue 114 type sequence D description BINDING SITE FOR RESIDUE CA A 271 source : AC1 3) chain A residue 116 type sequence E description BINDING SITE FOR RESIDUE CA A 271 source : AC1 4) chain A residue 121 type sequence E description BINDING SITE FOR RESIDUE CA A 271 source : AC1 5) chain A residue 154 type sequence D description BINDING SITE FOR RESIDUE CA A 272 source : AC2 6) chain A residue 156 type sequence D description BINDING SITE FOR RESIDUE CA A 272 source : AC2 7) chain A residue 158 type sequence T description BINDING SITE FOR RESIDUE CA A 272 source : AC2 8) chain A residue 160 type sequence K description BINDING SITE FOR RESIDUE CA A 272 source : AC2 9) chain A residue 165 type sequence E description BINDING SITE FOR RESIDUE CA A 272 source : AC2 10) chain A residue 184 type sequence D description BINDING SITE FOR RESIDUE CA A 273 source : AC3 11) chain A residue 186 type sequence D description BINDING SITE FOR RESIDUE CA A 273 source : AC3 12) chain A residue 188 type sequence S description BINDING SITE FOR RESIDUE CA A 273 source : AC3 13) chain A residue 190 type sequence T description BINDING SITE FOR RESIDUE CA A 273 source : AC3 14) chain A residue 195 type sequence E description BINDING SITE FOR RESIDUE CA A 273 source : AC3 15) chain A residue 139 type sequence D description BINDING SITE FOR RESIDUE CA A 274 source : AC4 16) chain A residue 227 type sequence D description BINDING SITE FOR RESIDUE CA A 274 source : AC4 17) chain A residue 229 type sequence D description BINDING SITE FOR RESIDUE CA A 274 source : AC4 18) chain A residue 230 type sequence N description BINDING SITE FOR RESIDUE CA A 274 source : AC4 19) chain B residue 111 type sequence A description BINDING SITE FOR RESIDUE CA B 275 source : AC5 20) chain B residue 114 type sequence D description BINDING SITE FOR RESIDUE CA B 275 source : AC5 21) chain B residue 116 type sequence E description BINDING SITE FOR RESIDUE CA B 275 source : AC5 22) chain B residue 121 type sequence E description BINDING SITE FOR RESIDUE CA B 275 source : AC5 23) chain B residue 154 type sequence D description BINDING SITE FOR RESIDUE CA B 276 source : AC6 24) chain B residue 156 type sequence D description BINDING SITE FOR RESIDUE CA B 276 source : AC6 25) chain B residue 158 type sequence T description BINDING SITE FOR RESIDUE CA B 276 source : AC6 26) chain B residue 160 type sequence K description BINDING SITE FOR RESIDUE CA B 276 source : AC6 27) chain B residue 165 type sequence E description BINDING SITE FOR RESIDUE CA B 276 source : AC6 28) chain B residue 184 type sequence D description BINDING SITE FOR RESIDUE CA B 277 source : AC7 29) chain B residue 186 type sequence D description BINDING SITE FOR RESIDUE CA B 277 source : AC7 30) chain B residue 188 type sequence S description BINDING SITE FOR RESIDUE CA B 277 source : AC7 31) chain B residue 190 type sequence T description BINDING SITE FOR RESIDUE CA B 277 source : AC7 32) chain B residue 195 type sequence E description BINDING SITE FOR RESIDUE CA B 277 source : AC7 33) chain B residue 139 type sequence D description BINDING SITE FOR RESIDUE CA B 278 source : AC8 34) chain B residue 227 type sequence D description BINDING SITE FOR RESIDUE CA B 278 source : AC8 35) chain B residue 229 type sequence D description BINDING SITE FOR RESIDUE CA B 278 source : AC8 36) chain B residue 230 type sequence N description BINDING SITE FOR RESIDUE CA B 278 source : AC8 37) chain A residue 154-166 type prosite sequence DSDTTGKLGFEEF description EF_HAND_1 EF-hand calcium-binding domain. DSDTTGKLGfeEF source prosite : PS00018 38) chain A residue 184-196 type prosite sequence DTDRSGTIGSNEL description EF_HAND_1 EF-hand calcium-binding domain. DSDTTGKLGfeEF source prosite : PS00018 39) chain A residue 181 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P04632 source Swiss-Prot : SWS_FT_FI5 40) chain B residue 181 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P04632 source Swiss-Prot : SWS_FT_FI5 41) chain A residue 111 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 121 type BINDING sequence E description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 139 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 227 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 114 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 116 type BINDING sequence E description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 121 type BINDING sequence E description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 139 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 49) chain A residue 227 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 50) chain B residue 111 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 51) chain B residue 114 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 52) chain B residue 116 type BINDING sequence E description BINDING => ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 154 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 54) chain A residue 195 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 55) chain B residue 154 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 56) chain B residue 156 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 158 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 160 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 59) chain B residue 165 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 60) chain B residue 184 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 61) chain B residue 186 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 62) chain B residue 188 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 63) chain B residue 190 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 64) chain A residue 156 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 65) chain B residue 195 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 66) chain A residue 158 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 67) chain A residue 160 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 68) chain A residue 165 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 69) chain A residue 184 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 70) chain A residue 186 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 71) chain A residue 188 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2 72) chain A residue 190 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623, ECO:0000269|PubMed:9228945, ECO:0007744|PDB:1DVI, ECO:0007744|PDB:3BOW, ECO:0007744|PDB:3DF0 source Swiss-Prot : SWS_FT_FI2

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