eF-site ID 1dt7_21-ABXY
PDB Code 1dt7
Model 21
Chain A, B, X, Y

click to enlarge
Title SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)
Classification SIGNALING PROTEIN
Compound S100 CALCIUM-BINDING PROTEIN
Source Rattus norvegicus (Rat) (P53_HUMAN)
Sequence A:  MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNE
LSHFLEEIKEQEVVDKVMETLDEDGDGECDFQEFMAFVSM
VTTACHEFFEHE
B:  MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNE
LSHFLEEIKEQEVVDKVMETLDEDGDGECDFQEFMAFVSM
VTTACHEFFEHE
X:  SHLKSKKGQSTSRHKKLMFKTE
Y:  SHLKSKKGQSTSRHKKLMFKTE
Description (1)  S100 CALCIUM-BINDING PROTEIN


Functional site

1) chain A
residue 18
type
sequence S
description BINDING SITE FOR RESIDUE CA A 114
source : AC1

2) chain A
residue 23
type
sequence D
description BINDING SITE FOR RESIDUE CA A 114
source : AC1

3) chain A
residue 26
type
sequence K
description BINDING SITE FOR RESIDUE CA A 114
source : AC1

4) chain A
residue 27
type
sequence L
description BINDING SITE FOR RESIDUE CA A 114
source : AC1

5) chain A
residue 31
type
sequence E
description BINDING SITE FOR RESIDUE CA A 114
source : AC1

6) chain A
residue 61
type
sequence D
description BINDING SITE FOR RESIDUE CA A 115
source : AC2

7) chain A
residue 62
type
sequence E
description BINDING SITE FOR RESIDUE CA A 115
source : AC2

8) chain A
residue 63
type
sequence D
description BINDING SITE FOR RESIDUE CA A 115
source : AC2

9) chain A
residue 64
type
sequence G
description BINDING SITE FOR RESIDUE CA A 115
source : AC2

10) chain A
residue 65
type
sequence D
description BINDING SITE FOR RESIDUE CA A 115
source : AC2

11) chain A
residue 67
type
sequence E
description BINDING SITE FOR RESIDUE CA A 115
source : AC2

12) chain A
residue 72
type
sequence E
description BINDING SITE FOR RESIDUE CA A 115
source : AC2

13) chain B
residue 18
type
sequence S
description BINDING SITE FOR RESIDUE CA B 116
source : AC3

14) chain B
residue 23
type
sequence D
description BINDING SITE FOR RESIDUE CA B 116
source : AC3

15) chain B
residue 26
type
sequence K
description BINDING SITE FOR RESIDUE CA B 116
source : AC3

16) chain B
residue 31
type
sequence E
description BINDING SITE FOR RESIDUE CA B 116
source : AC3

17) chain B
residue 61
type
sequence D
description BINDING SITE FOR RESIDUE CA B 117
source : AC4

18) chain B
residue 62
type
sequence E
description BINDING SITE FOR RESIDUE CA B 117
source : AC4

19) chain B
residue 63
type
sequence D
description BINDING SITE FOR RESIDUE CA B 117
source : AC4

20) chain B
residue 64
type
sequence G
description BINDING SITE FOR RESIDUE CA B 117
source : AC4

21) chain B
residue 65
type
sequence D
description BINDING SITE FOR RESIDUE CA B 117
source : AC4

22) chain B
residue 67
type
sequence E
description BINDING SITE FOR RESIDUE CA B 117
source : AC4

23) chain B
residue 72
type
sequence E
description BINDING SITE FOR RESIDUE CA B 117
source : AC4

24) chain X
residue 106
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:29474172, ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI4

25) chain Y
residue 106
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:29474172, ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI4

26) chain X
residue 107
type MOD_RES
sequence K
description N6-methyllysine; by KMT5A; alternate => ECO:0000269|PubMed:17707234, ECO:0000269|PubMed:20870725, ECO:0000269|PubMed:22864287
source Swiss-Prot : SWS_FT_FI5

27) chain Y
residue 107
type MOD_RES
sequence K
description N6-methyllysine; by KMT5A; alternate => ECO:0000269|PubMed:17707234, ECO:0000269|PubMed:20870725, ECO:0000269|PubMed:22864287
source Swiss-Prot : SWS_FT_FI5

28) chain X
residue 95
type MOD_RES
sequence K
description N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287
source Swiss-Prot : SWS_FT_FI1

29) chain Y
residue 95
type MOD_RES
sequence K
description N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287
source Swiss-Prot : SWS_FT_FI1

30) chain A
residue 85
type MOD_RES
sequence H
description N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287
source Swiss-Prot : SWS_FT_FI1

31) chain A
residue 90
type MOD_RES
sequence H
description N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287
source Swiss-Prot : SWS_FT_FI1

32) chain B
residue 15
type MOD_RES
sequence H
description N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287
source Swiss-Prot : SWS_FT_FI1

33) chain B
residue 25
type MOD_RES
sequence H
description N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287
source Swiss-Prot : SWS_FT_FI1

34) chain B
residue 85
type MOD_RES
sequence H
description N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287
source Swiss-Prot : SWS_FT_FI1

35) chain B
residue 90
type MOD_RES
sequence H
description N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287
source Swiss-Prot : SWS_FT_FI1

36) chain X
residue 97
type MOD_RES
sequence K
description N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881
source Swiss-Prot : SWS_FT_FI2

37) chain Y
residue 97
type MOD_RES
sequence K
description N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881
source Swiss-Prot : SWS_FT_FI2

38) chain A
residue 26
type MOD_RES
sequence K
description N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881
source Swiss-Prot : SWS_FT_FI2

39) chain A
residue 31
type MOD_RES
sequence E
description N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881
source Swiss-Prot : SWS_FT_FI2

40) chain B
residue 18
type MOD_RES
sequence S
description N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881
source Swiss-Prot : SWS_FT_FI2

41) chain B
residue 21
type MOD_RES
sequence E
description N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881
source Swiss-Prot : SWS_FT_FI2

42) chain B
residue 26
type MOD_RES
sequence K
description N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881
source Swiss-Prot : SWS_FT_FI2

43) chain B
residue 31
type MOD_RES
sequence E
description N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881
source Swiss-Prot : SWS_FT_FI2

44) chain X
residue 98
type MOD_RES
sequence K
description N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
source Swiss-Prot : SWS_FT_FI3

45) chain B
residue 72
type MOD_RES
sequence E
description N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
source Swiss-Prot : SWS_FT_FI3

46) chain Y
residue 98
type MOD_RES
sequence K
description N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
source Swiss-Prot : SWS_FT_FI3

47) chain A
residue 65
type MOD_RES
sequence D
description N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
source Swiss-Prot : SWS_FT_FI3

48) chain A
residue 67
type MOD_RES
sequence E
description N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
source Swiss-Prot : SWS_FT_FI3

49) chain A
residue 72
type MOD_RES
sequence E
description N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
source Swiss-Prot : SWS_FT_FI3

50) chain B
residue 61
type MOD_RES
sequence D
description N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
source Swiss-Prot : SWS_FT_FI3

51) chain B
residue 63
type MOD_RES
sequence D
description N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
source Swiss-Prot : SWS_FT_FI3

52) chain B
residue 65
type MOD_RES
sequence D
description N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
source Swiss-Prot : SWS_FT_FI3

53) chain B
residue 67
type MOD_RES
sequence E
description N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
source Swiss-Prot : SWS_FT_FI3

54) chain X
residue 111
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:11124955, ECO:0000269|PubMed:22214662, ECO:0000269|Ref.37
source Swiss-Prot : SWS_FT_FI6

55) chain Y
residue 111
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:11124955, ECO:0000269|PubMed:22214662, ECO:0000269|Ref.37
source Swiss-Prot : SWS_FT_FI6

56) chain A
residue 61-73
type prosite
sequence DEDGDGECDFQEF
description EF_HAND_1 EF-hand calcium-binding domain. DEDGDGECDfqEF
source prosite : PS00018

57) chain A
residue 56-77
type prosite
sequence VMETLDEDGDGECDFQEFMAFV
description S100_CABP S-100/ICaBP type calcium binding protein signature. VMetLDedgDgecDFqEFmaFV
source prosite : PS00303


Display surface

Download
Links