eF-site ID 1dt6-A PDB Code 1dt6 Chain A click to enlarge Title STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5 Classification OXIDOREDUCTASE Compound CYTOCHROME P450 2C5 Source (CP2C5_RABIT) Sequence A:  PPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYL GMKPTVVLHGYEAVKEALVDLGEEFAGRGSVPILEKVSKG LGIAFSNAKTWKEMRRFSLMTLRNFGMGKRSIEDRIQEEA RCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDY KDEEFLKLMESLHENVELLGTPLDYFPGIHKTLLKNADYI KNFIMEKVKEHQKLLDVNNPRDFIDCFLIKMEQENNLEFT LESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARV QEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLP TNLPHAVTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPN PKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGEGLARM ELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSY QLCFIPIHH Description Functional site 1) chain A residue 199 type sequence E description BINDING SITE FOR RESIDUE SM A 502 source : AC1 2) chain A residue 199 type sequence E description BINDING SITE FOR RESIDUE SM A 502 source : AC1 3) chain A residue 203 type sequence E description BINDING SITE FOR RESIDUE SM A 502 source : AC1 4) chain A residue 203 type sequence E description BINDING SITE FOR RESIDUE SM A 502 source : AC1 5) chain A residue 132 type sequence R description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 6) chain A residue 133 type sequence N description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 7) chain A residue 454 type sequence K description BINDING SITE FOR RESIDUE SO4 A 503 source : AC2 8) chain A residue 138 type sequence K description BINDING SITE FOR RESIDUE SO4 A 504 source : AC3 9) chain A residue 259 type sequence N description BINDING SITE FOR RESIDUE SO4 A 504 source : AC3 10) chain A residue 261 type sequence R description BINDING SITE FOR RESIDUE SO4 A 504 source : AC3 11) chain A residue 411 type sequence D description BINDING SITE FOR RESIDUE SO4 A 505 source : AC4 12) chain A residue 412 type sequence E description BINDING SITE FOR RESIDUE SO4 A 505 source : AC4 13) chain A residue 418 type sequence K description BINDING SITE FOR RESIDUE SO4 A 505 source : AC4 14) chain A residue 112 type sequence I description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 15) chain A residue 113 type sequence A description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 16) chain A residue 120 type sequence W description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 17) chain A residue 124 type sequence R description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 18) chain A residue 294 type sequence A description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 19) chain A residue 295 type sequence G description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 20) chain A residue 298 type sequence T description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 21) chain A residue 299 type sequence T description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 22) chain A residue 302 type sequence T description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 23) chain A residue 359 type sequence L description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 24) chain A residue 362 type sequence N description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 25) chain A residue 363 type sequence L description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 26) chain A residue 365 type sequence H description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 27) chain A residue 424 type sequence P description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 28) chain A residue 425 type sequence F description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 29) chain A residue 426 type sequence S description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 30) chain A residue 430 type sequence R description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 31) chain A residue 432 type sequence C description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 32) chain A residue 433 type sequence V description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 33) chain A residue 438 type sequence A description BINDING SITE FOR RESIDUE HEM A 501 source : AC5 34) chain A residue 425-434 type prosite sequence FSAGKRMCVG description CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSaGKRMCVG source prosite : PS00086 35) chain A residue 432 type BINDING sequence C description axial binding residue source Swiss-Prot : SWS_FT_FI1

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