eF-site ID 1dsz-ABCD PDB Code 1dsz Chain A, B, C, D click to enlarge Title STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1 Classification TRANSCRIPTION/DNA Compound DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3') Source Homo sapiens (Human) (1DSZ) Sequence A:  PCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHR DKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND B:  GSFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDL TYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQE ERQR C:  CAGGTCAAAGGTCAG D:  CTGACCTTTGACCTG Description Functional site 1) chain A residue 1135 type sequence C description BINDING SITE FOR RESIDUE ZN A 1121 source : AC1 2) chain A residue 1138 type sequence C description BINDING SITE FOR RESIDUE ZN A 1121 source : AC1 3) chain A residue 1152 type sequence C description BINDING SITE FOR RESIDUE ZN A 1121 source : AC1 4) chain A residue 1155 type sequence C description BINDING SITE FOR RESIDUE ZN A 1121 source : AC1 5) chain A residue 1171 type sequence C description BINDING SITE FOR RESIDUE ZN A 1122 source : AC2 6) chain A residue 1177 type sequence C description BINDING SITE FOR RESIDUE ZN A 1122 source : AC2 7) chain A residue 1187 type sequence C description BINDING SITE FOR RESIDUE ZN A 1122 source : AC2 8) chain A residue 1190 type sequence C description BINDING SITE FOR RESIDUE ZN A 1122 source : AC2 9) chain B residue 1235 type sequence C description BINDING SITE FOR RESIDUE ZN B 1221 source : AC3 10) chain B residue 1238 type sequence C description BINDING SITE FOR RESIDUE ZN B 1221 source : AC3 11) chain B residue 1252 type sequence C description BINDING SITE FOR RESIDUE ZN B 1221 source : AC3 12) chain B residue 1255 type sequence C description BINDING SITE FOR RESIDUE ZN B 1221 source : AC3 13) chain B residue 1271 type sequence C description BINDING SITE FOR RESIDUE ZN B 1222 source : AC4 14) chain B residue 1277 type sequence C description BINDING SITE FOR RESIDUE ZN B 1222 source : AC4 15) chain B residue 1287 type sequence C description BINDING SITE FOR RESIDUE ZN B 1222 source : AC4 16) chain B residue 1290 type sequence C description BINDING SITE FOR RESIDUE ZN B 1222 source : AC4 17) chain B residue 1235 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4 source Swiss-Prot : SWS_FT_FI3 18) chain B residue 1238 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4 source Swiss-Prot : SWS_FT_FI3 19) chain B residue 1252 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4 source Swiss-Prot : SWS_FT_FI3 20) chain B residue 1255 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4 source Swiss-Prot : SWS_FT_FI3 21) chain B residue 1271 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4 source Swiss-Prot : SWS_FT_FI3 22) chain B residue 1277 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 1287 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4 source Swiss-Prot : SWS_FT_FI3 24) chain B residue 1290 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 1235-1300 type DNA_BIND sequence CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDN KDCLIDKRQRNRCQYCRYQKCLAMGM description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 1235-1255 type ZN_FING sequence CAICGDRSSGKHYGVYSCEGC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 1271-1295 type ZN_FING sequence CRDNKDCLIDKRQRNRCQYCRYQKC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 1229 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 29) chain B residue 1245 type MOD_RES sequence K description N6-acetyllysine; by EP300 => ECO:0000269|PubMed:17761950 source Swiss-Prot : SWS_FT_FI5 30) chain A residue 1135-1161 type prosite sequence CFVCQDKSSGYHYGVSACEGCKGFFRR description NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CfvCq.Dkssgy.HYgvsaCegCkgFFrR source prosite : PS00031 31) chain B residue 1235-1261 type prosite sequence CAICGDRSSGKHYGVYSCEGCKGFFKR description NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CfvCq.Dkssgy.HYgvsaCegCkgFFrR source prosite : PS00031

Display surface Download Links