eF-site ID 1drb-B PDB Code 1drb Chain B click to enlarge Title CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING Classification OXIDOREDUCTASE Compound DIHYDROFOLATE REDUCTASE Source Escherichia coli (strain K12) (DYR_ECOLI) Sequence B:  MISLIAALAVDRVIGMENAMPWNLPACLAWFKRNTLDKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Description Functional site 1) chain B residue 5 type sequence I description source : BPT 2) chain B residue 6 type sequence A description source : BPT 3) chain B residue 7 type sequence A description source : BPT 4) chain B residue 22 type sequence W description source : BPT 5) chain B residue 27 type sequence C description source : BPT 6) chain B residue 28 type sequence L description source : BPT 7) chain B residue 31 type sequence F description source : BPT 8) chain B residue 94 type sequence I description source : BPT 9) chain B residue 113 type sequence T description source : BPT 10) chain B residue 49 type sequence S description source : BNM 11) chain B residue 28 type sequence L description source : BAB 12) chain B residue 31 type sequence F description source : BAB 13) chain B residue 50 type sequence I description source : BAB 14) chain B residue 52 type sequence R description source : BAB 15) chain B residue 54 type sequence L description source : BAB 16) chain B residue 28 type sequence L description source : BGL 17) chain B residue 31 type sequence F description source : BGL 18) chain B residue 32 type sequence K description source : BGL 19) chain B residue 54 type sequence L description source : BGL 20) chain B residue 57 type sequence R description source : BGL 21) chain B residue 43 type sequence G description BINDING SITE FOR RESIDUE CL B 605 source : AC2 22) chain B residue 45 type sequence H description BINDING SITE FOR RESIDUE CL B 605 source : AC2 23) chain B residue 46 type sequence T description BINDING SITE FOR RESIDUE CL B 605 source : AC2 24) chain B residue 96 type sequence G description BINDING SITE FOR RESIDUE CL B 605 source : AC2 25) chain B residue 135 type sequence S description BINDING SITE FOR RESIDUE CA B 620 source : AC3 26) chain B residue 5 type sequence I description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 27) chain B residue 6 type sequence A description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 28) chain B residue 7 type sequence A description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 29) chain B residue 31 type sequence F description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 30) chain B residue 32 type sequence K description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 31) chain B residue 50 type sequence I description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 32) chain B residue 52 type sequence R description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 33) chain B residue 57 type sequence R description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 34) chain B residue 94 type sequence I description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 35) chain B residue 100 type sequence Y description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 36) chain B residue 113 type sequence T description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 37) chain B residue 7 type sequence A description BINDING SITE FOR RESIDUE EOH B 918 source : AC7 38) chain B residue 27 type sequence C description BINDING SITE FOR RESIDUE EOH B 918 source : AC7

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