eF-site ID 1drb-AB PDB Code 1drb Chain A, B click to enlarge Title CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING Classification OXIDOREDUCTASE Compound DIHYDROFOLATE REDUCTASE Source null (DYR_ECOLI) Sequence A:  MISLIAALAVDRVIGMENAMPWNLPACLAWFKRNTLDKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR B:  MISLIAALAVDRVIGMENAMPWNLPACLAWFKRNTLDKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Description Functional site 1) chain A residue 5 type sequence I description source : APT 2) chain A residue 6 type sequence A description source : APT 3) chain A residue 7 type sequence A description source : APT 4) chain A residue 22 type sequence W description source : APT 5) chain A residue 27 type sequence C description source : APT 6) chain A residue 28 type sequence L description source : APT 7) chain A residue 31 type sequence F description source : APT 8) chain A residue 94 type sequence I description source : APT 9) chain A residue 113 type sequence T description source : APT 10) chain A residue 49 type sequence S description source : ANM 11) chain A residue 28 type sequence L description source : AAB 12) chain A residue 31 type sequence F description source : AAB 13) chain A residue 50 type sequence I description source : AAB 14) chain A residue 52 type sequence R description source : AAB 15) chain A residue 54 type sequence L description source : AAB 16) chain A residue 28 type sequence L description source : AGL 17) chain A residue 31 type sequence F description source : AGL 18) chain A residue 32 type sequence K description source : AGL 19) chain A residue 54 type sequence L description source : AGL 20) chain A residue 57 type sequence R description source : AGL 21) chain B residue 5 type sequence I description source : BPT 22) chain B residue 6 type sequence A description source : BPT 23) chain B residue 7 type sequence A description source : BPT 24) chain B residue 22 type sequence W description source : BPT 25) chain B residue 27 type sequence C description source : BPT 26) chain B residue 28 type sequence L description source : BPT 27) chain B residue 31 type sequence F description source : BPT 28) chain B residue 94 type sequence I description source : BPT 29) chain B residue 113 type sequence T description source : BPT 30) chain B residue 49 type sequence S description source : BNM 31) chain B residue 28 type sequence L description source : BAB 32) chain B residue 31 type sequence F description source : BAB 33) chain B residue 50 type sequence I description source : BAB 34) chain B residue 52 type sequence R description source : BAB 35) chain B residue 54 type sequence L description source : BAB 36) chain B residue 28 type sequence L description source : BGL 37) chain B residue 31 type sequence F description source : BGL 38) chain B residue 32 type sequence K description source : BGL 39) chain B residue 54 type sequence L description source : BGL 40) chain B residue 57 type sequence R description source : BGL 41) chain A residue 43 type sequence G description BINDING SITE FOR RESIDUE CL A 401 source : AC1 42) chain A residue 45 type sequence H description BINDING SITE FOR RESIDUE CL A 401 source : AC1 43) chain A residue 46 type sequence T description BINDING SITE FOR RESIDUE CL A 401 source : AC1 44) chain A residue 96 type sequence G description BINDING SITE FOR RESIDUE CL A 401 source : AC1 45) chain B residue 43 type sequence G description BINDING SITE FOR RESIDUE CL B 605 source : AC2 46) chain B residue 45 type sequence H description BINDING SITE FOR RESIDUE CL B 605 source : AC2 47) chain B residue 46 type sequence T description BINDING SITE FOR RESIDUE CL B 605 source : AC2 48) chain B residue 96 type sequence G description BINDING SITE FOR RESIDUE CL B 605 source : AC2 49) chain B residue 135 type sequence S description BINDING SITE FOR RESIDUE CA B 620 source : AC3 50) chain A residue 5 type sequence I description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 51) chain A residue 6 type sequence A description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 52) chain A residue 7 type sequence A description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 53) chain A residue 31 type sequence F description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 54) chain A residue 32 type sequence K description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 55) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 56) chain A residue 52 type sequence R description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 57) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 58) chain A residue 94 type sequence I description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 59) chain A residue 100 type sequence Y description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 60) chain A residue 113 type sequence T description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 61) chain B residue 5 type sequence I description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 62) chain B residue 6 type sequence A description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 63) chain B residue 7 type sequence A description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 64) chain B residue 31 type sequence F description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 65) chain B residue 32 type sequence K description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 66) chain B residue 50 type sequence I description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 67) chain B residue 52 type sequence R description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 68) chain B residue 57 type sequence R description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 69) chain B residue 94 type sequence I description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 70) chain B residue 100 type sequence Y description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 71) chain B residue 113 type sequence T description BINDING SITE FOR RESIDUE MTX B 361 source : AC5 72) chain A residue 27 type sequence C description BINDING SITE FOR RESIDUE EOH A 900 source : AC6 73) chain B residue 7 type sequence A description BINDING SITE FOR RESIDUE EOH B 918 source : AC7 74) chain B residue 27 type sequence C description BINDING SITE FOR RESIDUE EOH B 918 source : AC7 75) chain A residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 76) chain A residue 27 type BINDING sequence C description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 77) chain A residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 78) chain A residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 79) chain A residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 80) chain B residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 81) chain B residue 27 type BINDING sequence C description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 82) chain B residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 83) chain B residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 84) chain B residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 85) chain B residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 86) chain B residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 87) chain B residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 88) chain A residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 89) chain A residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 90) chain A residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 91) chain A residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 92) chain B residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 93) chain B residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 95) chain A residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 96) chain A residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2

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