eF-site ID 1drb-A PDB Code 1drb Chain A click to enlarge Title CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING Classification OXIDOREDUCTASE Compound DIHYDROFOLATE REDUCTASE Source Escherichia coli (strain K12) (DYR_ECOLI) Sequence A:  MISLIAALAVDRVIGMENAMPWNLPACLAWFKRNTLDKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Description Functional site 1) chain A residue 5 type sequence I description source : APT 2) chain A residue 6 type sequence A description source : APT 3) chain A residue 7 type sequence A description source : APT 4) chain A residue 22 type sequence W description source : APT 5) chain A residue 27 type sequence C description source : APT 6) chain A residue 28 type sequence L description source : APT 7) chain A residue 31 type sequence F description source : APT 8) chain A residue 94 type sequence I description source : APT 9) chain A residue 113 type sequence T description source : APT 10) chain A residue 49 type sequence S description source : ANM 11) chain A residue 28 type sequence L description source : AAB 12) chain A residue 31 type sequence F description source : AAB 13) chain A residue 50 type sequence I description source : AAB 14) chain A residue 52 type sequence R description source : AAB 15) chain A residue 54 type sequence L description source : AAB 16) chain A residue 28 type sequence L description source : AGL 17) chain A residue 31 type sequence F description source : AGL 18) chain A residue 32 type sequence K description source : AGL 19) chain A residue 54 type sequence L description source : AGL 20) chain A residue 57 type sequence R description source : AGL 21) chain A residue 43 type sequence G description BINDING SITE FOR RESIDUE CL A 401 source : AC1 22) chain A residue 45 type sequence H description BINDING SITE FOR RESIDUE CL A 401 source : AC1 23) chain A residue 46 type sequence T description BINDING SITE FOR RESIDUE CL A 401 source : AC1 24) chain A residue 96 type sequence G description BINDING SITE FOR RESIDUE CL A 401 source : AC1 25) chain A residue 5 type sequence I description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 26) chain A residue 6 type sequence A description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 27) chain A residue 7 type sequence A description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 28) chain A residue 31 type sequence F description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 29) chain A residue 32 type sequence K description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 30) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 31) chain A residue 52 type sequence R description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 32) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 33) chain A residue 94 type sequence I description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 34) chain A residue 100 type sequence Y description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 35) chain A residue 113 type sequence T description BINDING SITE FOR RESIDUE MTX A 161 source : AC4 36) chain A residue 27 type sequence C description BINDING SITE FOR RESIDUE EOH A 900 source : AC6 37) chain A residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 27 type BINDING sequence C description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 45) chain A residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 46) chain A residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 47) chain A residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2

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