eF-site ID 1dr7-A PDB Code 1dr7 Chain A click to enlarge Title CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES Classification OXIDOREDUCTASE Compound DIHYDROFOLATE REDUCTASE Source null (DYR_CHICK) Sequence A:  VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTST SHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELK EAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAV YKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLT EYPGVPADIQEEDGIQYKFEVYQKSV Description Functional site 1) chain A residue 78 type sequence E description BINDING SITE FOR RESIDUE CA A 200 source : AC1 2) chain A residue 78 type sequence E description BINDING SITE FOR RESIDUE CA A 200 source : AC1 3) chain A residue 8 type sequence V description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 4) chain A residue 9 type sequence A description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 5) chain A residue 16 type sequence I description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 6) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 7) chain A residue 20 type sequence G description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 8) chain A residue 21 type sequence N description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 9) chain A residue 22 type sequence L description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 10) chain A residue 53 type sequence G description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 11) chain A residue 54 type sequence K description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 12) chain A residue 55 type sequence K description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 13) chain A residue 56 type sequence T description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 14) chain A residue 75 type sequence L description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 15) chain A residue 76 type sequence S description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 16) chain A residue 77 type sequence R description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 17) chain A residue 78 type sequence E description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 18) chain A residue 78 type sequence E description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 19) chain A residue 91 type sequence K description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 20) chain A residue 92 type sequence S description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 21) chain A residue 115 type sequence V description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 22) chain A residue 117 type sequence G description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 23) chain A residue 118 type sequence T description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 24) chain A residue 119 type sequence A description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 25) chain A residue 120 type sequence V description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 26) chain A residue 121 type sequence Y description BINDING SITE FOR RESIDUE NAP A 191 source : AC2 27) chain A residue 11 type sequence C description BINDING SITE FOR RESIDUE MBO A 201 source : AC3 28) chain A residue 12 type sequence Q description BINDING SITE FOR RESIDUE MBO A 201 source : AC3 29) chain A residue 13 type sequence N description BINDING SITE FOR RESIDUE MBO A 201 source : AC3 30) chain A residue 140 type sequence H description BINDING SITE FOR RESIDUE MBO A 201 source : AC3 31) chain A residue 141 type sequence E description BINDING SITE FOR RESIDUE MBO A 201 source : AC3 32) chain A residue 142 type sequence F description BINDING SITE FOR RESIDUE MBO A 201 source : AC3 33) chain A residue 144 type sequence S description BINDING SITE FOR RESIDUE MBO A 201 source : AC3 34) chain A residue 9 type BINDING sequence A description BINDING => ECO:0000269|PubMed:1510919, ECO:0007744|PDB:1DR1 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 54 type BINDING sequence K description BINDING => ECO:0000269|PubMed:1510919, ECO:0007744|PDB:1DR1 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 76 type BINDING sequence S description BINDING => ECO:0000269|PubMed:1510919, ECO:0007744|PDB:1DR1 source Swiss-Prot : SWS_FT_FI1 37) chain A residue 30 type BINDING sequence E description BINDING => ECO:0000305|PubMed:1510919 source Swiss-Prot : SWS_FT_FI2 38) chain A residue 15 type BINDING sequence G description BINDING => ECO:0000305|PubMed:1510919 source Swiss-Prot : SWS_FT_FI2 39) chain A residue 70 type BINDING sequence R description BINDING => ECO:0000305|PubMed:1510919 source Swiss-Prot : SWS_FT_FI2 40) chain A residue 116 type BINDING sequence G description BINDING => ECO:0000305|PubMed:1510919 source Swiss-Prot : SWS_FT_FI2 41) chain A residue 64 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P00374 source Swiss-Prot : SWS_FT_FI3 42) chain A residue 15-38 type prosite sequence GIGKDGNLPWPPLRNEYKYFQRMT description DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGkdgnLPWpplrnEykyFqrmT source prosite : PS00075

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