eF-site ID 1dq9-A PDB Code 1dq9 Chain A click to enlarge Title COMPLEX OF CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG-COA Classification OXIDOREDUCTASE Compound PROTEIN (HMG-COA REDUCTASE) Source Homo sapiens (Human) (HMDH_HUMAN) Sequence A:  FLSDAEIIQLVNAKHIPAYKLETLIETHERGVSIRRQLLS KKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGAS SRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKE AFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIE GRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGS AMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQM LGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAG HLVKS Description Functional site 1) chain A residue 559 type sequence E description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 2) chain A residue 564 type sequence A description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 3) chain A residue 565 type sequence S description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 4) chain A residue 567 type sequence N description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 5) chain A residue 568 type sequence R description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 6) chain A residue 571 type sequence R description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 7) chain A residue 720 type sequence V description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 8) chain A residue 722 type sequence K description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 9) chain A residue 735 type sequence K description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 10) chain A residue 751 type sequence A description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 11) chain A residue 752 type sequence H description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 12) chain A residue 852 type sequence S description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 13) chain A residue 853 type sequence L description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 14) chain A residue 856 type sequence A description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 15) chain A residue 862 type sequence L description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 16) chain A residue 865 type sequence S description BINDING SITE FOR RESIDUE HMG A 101 source : AC1 17) chain A residue 479 type sequence Y description BINDING SITE FOR RESIDUE HMG B 102 source : AC2 18) chain A residue 528 type sequence E description BINDING SITE FOR RESIDUE HMG B 102 source : AC2 19) chain A residue 590 type sequence R description BINDING SITE FOR RESIDUE HMG B 102 source : AC2 20) chain A residue 684 type sequence S description BINDING SITE FOR RESIDUE HMG B 102 source : AC2 21) chain A residue 690 type sequence D description BINDING SITE FOR RESIDUE HMG B 102 source : AC2 22) chain A residue 691 type sequence K description BINDING SITE FOR RESIDUE HMG B 102 source : AC2 23) chain A residue 692 type sequence K description BINDING SITE FOR RESIDUE HMG B 102 source : AC2 24) chain A residue 504 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 25) chain A residue 559 type ACT_SITE sequence E description Charge relay system => ECO:0000303|PubMed:10698924, ECO:0000303|PubMed:11349148 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 691 type ACT_SITE sequence K description Charge relay system => ECO:0000303|PubMed:10698924, ECO:0000303|PubMed:11349148 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 767 type ACT_SITE sequence D description Charge relay system => ECO:0000303|PubMed:10698924, ECO:0000303|PubMed:11349148 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 565 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11349148, ECO:0007744|PDB:1DQA source Swiss-Prot : SWS_FT_FI3 29) chain A residue 626 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11349148, ECO:0007744|PDB:1DQA source Swiss-Prot : SWS_FT_FI3 30) chain A residue 653 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11349148, ECO:0007744|PDB:1DQA source Swiss-Prot : SWS_FT_FI3 31) chain A residue 720 type BINDING sequence V description BINDING => ECO:0000269|PubMed:11349148, ECO:0007744|PDB:1DQA source Swiss-Prot : SWS_FT_FI3 32) chain A residue 865 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11349148, ECO:0007744|PDB:1DQA source Swiss-Prot : SWS_FT_FI3 33) chain A residue 559 type catalytic sequence E description 93 source MCSA : MCSA1 34) chain A residue 691 type catalytic sequence K description 93 source MCSA : MCSA1 35) chain A residue 767 type catalytic sequence D description 93 source MCSA : MCSA1 36) chain A residue 646-660 type prosite sequence RFQSRSGDAMGMNMI description HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. RfQSrSGDaMGmNmI source prosite : PS00066 37) chain A residue 802-809 type prosite sequence IGTVGGGT description HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. IGtVGGGT source prosite : PS00318

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