eF-site ID 1dm6-B PDB Code 1dm6 Chain B click to enlarge Title BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N-(4-CHLOROPHENYL)-N'-HYDROXYGUANIDINE (H4B FREE) Classification OXIDOREDUCTASE Compound NITRIC OXIDE SYNTHASE Source Bos taurus (Bovine) (NOS3_BOVIN) Sequence B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAH EERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVG RIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRS AITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPA NVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLP PELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGL EFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLD TRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVS FMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVN YILSPAFRYQPDPW Description Functional site 1) chain B residue 249 type sequence Q description BINDING SITE FOR RESIDUE ACT B 2850 source : AC4 2) chain B residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT B 2850 source : AC4 3) chain B residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT B 2850 source : AC4 4) chain B residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT B 2850 source : AC4 5) chain B residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT B 2860 source : AC5 6) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT B 2860 source : AC5 7) chain B residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT B 2860 source : AC5 8) chain B residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT B 2860 source : AC5 9) chain B residue 83 type sequence Y description BINDING SITE FOR RESIDUE CAC B 950 source : AC6 10) chain B residue 324 type sequence W description BINDING SITE FOR RESIDUE CAC B 950 source : AC6 11) chain B residue 384 type sequence C description BINDING SITE FOR RESIDUE CAC B 950 source : AC6 12) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC7 13) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC7 14) chain B residue 447 type sequence W description BINDING SITE FOR RESIDUE PH3 B 1785 source : BC1 15) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE PH3 B 1785 source : BC1 16) chain B residue 463 type sequence H description BINDING SITE FOR RESIDUE PH3 B 1785 source : BC1 17) chain B residue 464 type sequence Q description BINDING SITE FOR RESIDUE PH3 B 1785 source : BC1 18) chain B residue 465 type sequence E description BINDING SITE FOR RESIDUE PH3 B 1785 source : BC1 19) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 2500 source : BC2 20) chain B residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM B 2500 source : BC2 21) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 2500 source : BC2 22) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM B 2500 source : BC2 23) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 2500 source : BC2 24) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM B 2500 source : BC2 25) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 2500 source : BC2 26) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 2500 source : BC2 27) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 2500 source : BC2 28) chain B residue 475 type sequence F description BINDING SITE FOR RESIDUE HEM B 2500 source : BC2 29) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 2500 source : BC2 30) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE PH3 A 2785 source : BC3 31) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE PH3 A 2785 source : BC3 32) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE PH3 A 2785 source : BC3 33) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE PH3 A 2785 source : BC3 34) chain B residue 338 type sequence V description BINDING SITE FOR RESIDUE PH3 B 2780 source : BC4 35) chain B residue 357 type sequence G description BINDING SITE FOR RESIDUE PH3 B 2780 source : BC4 36) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE PH3 B 2780 source : BC4 37) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE PH3 B 2780 source : BC4 38) chain B residue 116 type MOD_RES sequence S description Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 39) chain B residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 44) chain B residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 45) chain B residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 46) chain B residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 47) chain B residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 48) chain B residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 49) chain B residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 50) chain B residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 51) chain B residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1

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