eF-site ID 1dm6-A PDB Code 1dm6 Chain A click to enlarge Title BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N-(4-CHLOROPHENYL)-N'-HYDROXYGUANIDINE (H4B FREE) Classification OXIDOREDUCTASE Compound NITRIC OXIDE SYNTHASE Source null (NOS3_BOVIN) Sequence A:  GPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLV LPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQ AHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRC VGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNL RSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGD PANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFV LPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIG GLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMD LDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAAT VSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEM VNYILSPAFRYQPDPW Description Functional site 1) chain A residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT A 1850 source : AC1 2) chain A residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT A 1850 source : AC1 3) chain A residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT A 1850 source : AC1 4) chain A residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT A 1860 source : AC2 5) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT A 1860 source : AC2 6) chain A residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT A 1860 source : AC2 7) chain A residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT A 1860 source : AC2 8) chain A residue 324 type sequence W description BINDING SITE FOR RESIDUE CAC A 950 source : AC3 9) chain A residue 384 type sequence C description BINDING SITE FOR RESIDUE CAC A 950 source : AC3 10) chain A residue 438 type sequence K description BINDING SITE FOR RESIDUE CAC A 950 source : AC3 11) chain A residue 441 type sequence G description BINDING SITE FOR RESIDUE CAC A 950 source : AC3 12) chain A residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC7 13) chain A residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC7 14) chain A residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM A 1500 source : AC8 15) chain A residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM A 1500 source : AC8 16) chain A residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM A 1500 source : AC8 17) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM A 1500 source : AC8 18) chain A residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM A 1500 source : AC8 19) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM A 1500 source : AC8 20) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM A 1500 source : AC8 21) chain A residue 475 type sequence F description BINDING SITE FOR RESIDUE HEM A 1500 source : AC8 22) chain A residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM A 1500 source : AC8 23) chain A residue 338 type sequence V description BINDING SITE FOR RESIDUE PH3 A 1780 source : AC9 24) chain A residue 357 type sequence G description BINDING SITE FOR RESIDUE PH3 A 1780 source : AC9 25) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE PH3 A 1780 source : AC9 26) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE PH3 A 1780 source : AC9 27) chain A residue 104 type sequence S description BINDING SITE FOR RESIDUE PH3 B 1785 source : BC1 28) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE PH3 B 1785 source : BC1 29) chain A residue 448 type sequence A description BINDING SITE FOR RESIDUE PH3 B 1785 source : BC1 30) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE PH3 B 1785 source : BC1 31) chain A residue 447 type sequence W description BINDING SITE FOR RESIDUE PH3 A 2785 source : BC3 32) chain A residue 462 type sequence F description BINDING SITE FOR RESIDUE PH3 A 2785 source : BC3 33) chain A residue 463 type sequence H description BINDING SITE FOR RESIDUE PH3 A 2785 source : BC3 34) chain A residue 464 type sequence Q description BINDING SITE FOR RESIDUE PH3 A 2785 source : BC3 35) chain A residue 465 type sequence E description BINDING SITE FOR RESIDUE PH3 A 2785 source : BC3 36) chain A residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 185-192 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 40) chain A residue 116 type MOD_RES sequence S description Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI4 41) chain A residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 45) chain A residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 46) chain A residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 47) chain A residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2

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