eF-site ID 1dkw-AB PDB Code 1dkw Chain A, B click to enlarge Title CRYSTAL STRUCTURE OF TRIOSE-PHOSPHATE ISOMERASE WITH MODIFIED SUBSTRATE BINDING SITE Classification ISOMERASE Compound TRIOSEPHOSPHATE ISOMERASE Source Trypanosoma brucei brucei (TPIS_TRYBB) Sequence A:  SKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVVA STFVHLAMTKERLSHPKFVIAAQNAGNEDSLPSLKDFGVN WIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGE TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV WAIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRIL YGGSVNGKNARTLYQQRDVNGFLVGLKPEFVDIIKATQ B:  SKPQPIAAANWKDSLSELIDLFNSTSINHDVQCVVASTFV HLAMTKERLSHPKFVIAAQNAGNEDSLPSLKDFGVNWIVL GHSERRWYYGETNEIVADKVAAAVASGFMVIACIGETLQE RESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIG TGKVATPQQAQEAHALIRSWVSSKIGADVAGELRILYGGS VNGKNARTLYQQRDVNGFLVGLKPEFVDIIKATQ Description Functional site 1) chain B residue 100 type sequence W description BINDING SITE FOR RESIDUE TBU B 252 source : AC2 2) chain B residue 133 type sequence E description BINDING SITE FOR RESIDUE TBU B 252 source : AC2 3) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171 4) chain A residue 103 type ACT_SITE sequence G description Electrophile source Swiss-Prot : SWS_FT_FI1 5) chain B residue 103 type ACT_SITE sequence G description Electrophile source Swiss-Prot : SWS_FT_FI1 6) chain A residue 175 type ACT_SITE sequence G description Proton acceptor source Swiss-Prot : SWS_FT_FI2 7) chain B residue 175 type ACT_SITE sequence G description Proton acceptor source Swiss-Prot : SWS_FT_FI2 8) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 9) chain A residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 10) chain B residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 11) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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