eF-site ID 1djy-AB PDB Code 1djy Chain A, B click to enlarge Title PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-2,4,5-TRISPHOSPHATE Classification LIPID DEGRADATION Compound PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ISOZYME DELTA1 Source Rattus norvegicus (Rat) (PLCD1_RAT) Sequence A:  EIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQH QQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYL LSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQ LTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYT FTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQR VMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILLKG KKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASF SESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYS PVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVL KPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPK VNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPR WDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPW NSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD B:  NKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLE DEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFL QHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLM YLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLE DQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHG YTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQ QRVMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILL KGKKLGGLDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQ AFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGW RTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQD NGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRI ISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVI TNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDF IGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQ D Description Functional site 1) chain A residue 312 type sequence N description BINDING SITE FOR RESIDUE CA A 2 source : AC1 2) chain A residue 341 type sequence E description BINDING SITE FOR RESIDUE CA A 2 source : AC1 3) chain A residue 343 type sequence D description BINDING SITE FOR RESIDUE CA A 2 source : AC1 4) chain A residue 390 type sequence E description BINDING SITE FOR RESIDUE CA A 2 source : AC1 5) chain A residue 651 type sequence I description BINDING SITE FOR RESIDUE CA A 3 source : AC2 6) chain A residue 653 type sequence D description BINDING SITE FOR RESIDUE CA A 3 source : AC2 7) chain A residue 677 type sequence N description BINDING SITE FOR RESIDUE CA A 3 source : AC2 8) chain A residue 653 type sequence D description BINDING SITE FOR RESIDUE CA A 4 source : AC3 9) chain A residue 706 type sequence D description BINDING SITE FOR RESIDUE CA A 4 source : AC3 10) chain A residue 707 type sequence Y description BINDING SITE FOR RESIDUE CA A 4 source : AC3 11) chain A residue 583 type sequence G description BINDING SITE FOR RESIDUE ACT A 5 source : AC4 12) chain A residue 584 type sequence P description BINDING SITE FOR RESIDUE ACT A 5 source : AC4 13) chain A residue 587 type sequence D description BINDING SITE FOR RESIDUE ACT A 5 source : AC4 14) chain A residue 701 type sequence R description BINDING SITE FOR RESIDUE ACT A 5 source : AC4 15) chain A residue 715 type sequence F description BINDING SITE FOR RESIDUE ACT A 5 source : AC4 16) chain B residue 312 type sequence N description BINDING SITE FOR RESIDUE CA B 2 source : AC5 17) chain B residue 341 type sequence E description BINDING SITE FOR RESIDUE CA B 2 source : AC5 18) chain B residue 343 type sequence D description BINDING SITE FOR RESIDUE CA B 2 source : AC5 19) chain B residue 390 type sequence E description BINDING SITE FOR RESIDUE CA B 2 source : AC5 20) chain B residue 651 type sequence I description BINDING SITE FOR RESIDUE CA B 3 source : AC6 21) chain B residue 653 type sequence D description BINDING SITE FOR RESIDUE CA B 3 source : AC6 22) chain B residue 677 type sequence N description BINDING SITE FOR RESIDUE CA B 3 source : AC6 23) chain B residue 653 type sequence D description BINDING SITE FOR RESIDUE CA B 4 source : AC7 24) chain B residue 706 type sequence D description BINDING SITE FOR RESIDUE CA B 4 source : AC7 25) chain B residue 707 type sequence Y description BINDING SITE FOR RESIDUE CA B 4 source : AC7 26) chain B residue 708 type sequence D description BINDING SITE FOR RESIDUE CA B 4 source : AC7 27) chain B residue 583 type sequence G description BINDING SITE FOR RESIDUE ACT B 5 source : AC8 28) chain B residue 584 type sequence P description BINDING SITE FOR RESIDUE ACT B 5 source : AC8 29) chain B residue 587 type sequence D description BINDING SITE FOR RESIDUE ACT B 5 source : AC8 30) chain B residue 701 type sequence R description BINDING SITE FOR RESIDUE ACT B 5 source : AC8 31) chain B residue 715 type sequence F description BINDING SITE FOR RESIDUE ACT B 5 source : AC8 32) chain A residue 311 type sequence H description BINDING SITE FOR RESIDUE I2P A 1 source : AC9 33) chain A residue 312 type sequence N description BINDING SITE FOR RESIDUE I2P A 1 source : AC9 34) chain A residue 341 type sequence E description BINDING SITE FOR RESIDUE I2P A 1 source : AC9 35) chain A residue 343 type sequence D description BINDING SITE FOR RESIDUE I2P A 1 source : AC9 36) chain A residue 356 type sequence H description BINDING SITE FOR RESIDUE I2P A 1 source : AC9 37) chain A residue 390 type sequence E description BINDING SITE FOR RESIDUE I2P A 1 source : AC9 38) chain A residue 438 type sequence K description BINDING SITE FOR RESIDUE I2P A 1 source : AC9 39) chain A residue 522 type sequence S description BINDING SITE FOR RESIDUE I2P A 1 source : AC9 40) chain A residue 549 type sequence R description BINDING SITE FOR RESIDUE I2P A 1 source : AC9 41) chain A residue 551 type sequence Y description BINDING SITE FOR RESIDUE I2P A 1 source : AC9 42) chain B residue 311 type sequence H description BINDING SITE FOR RESIDUE I2P B 1 source : BC1 43) chain B residue 312 type sequence N description BINDING SITE FOR RESIDUE I2P B 1 source : BC1 44) chain B residue 341 type sequence E description BINDING SITE FOR RESIDUE I2P B 1 source : BC1 45) chain B residue 343 type sequence D description BINDING SITE FOR RESIDUE I2P B 1 source : BC1 46) chain B residue 356 type sequence H description BINDING SITE FOR RESIDUE I2P B 1 source : BC1 47) chain B residue 388 type sequence S description BINDING SITE FOR RESIDUE I2P B 1 source : BC1 48) chain B residue 390 type sequence E description BINDING SITE FOR RESIDUE I2P B 1 source : BC1 49) chain B residue 438 type sequence K description BINDING SITE FOR RESIDUE I2P B 1 source : BC1 50) chain B residue 522 type sequence S description BINDING SITE FOR RESIDUE I2P B 1 source : BC1 51) chain B residue 549 type sequence R description BINDING SITE FOR RESIDUE I2P B 1 source : BC1 52) chain B residue 551 type sequence Y description BINDING SITE FOR RESIDUE I2P B 1 source : BC1 53) chain A residue 311 type ACT_SITE sequence H description source Swiss-Prot : SWS_FT_FI1 54) chain A residue 356 type ACT_SITE sequence H description source Swiss-Prot : SWS_FT_FI1 55) chain B residue 311 type ACT_SITE sequence H description source Swiss-Prot : SWS_FT_FI1 56) chain B residue 356 type ACT_SITE sequence H description source Swiss-Prot : SWS_FT_FI1 57) chain A residue 200 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 159 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 59) chain B residue 164 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 60) chain B residue 189 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 61) chain B residue 191 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 62) chain B residue 193 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 63) chain B residue 195 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 64) chain B residue 200 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 65) chain A residue 312 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 66) chain A residue 653 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 67) chain A residue 677 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 68) chain A residue 706 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 69) chain A residue 707 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 70) chain A residue 708 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 71) chain B residue 312 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 72) chain B residue 341 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 73) chain B residue 343 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 74) chain B residue 390 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 75) chain B residue 438 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 76) chain A residue 341 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 77) chain B residue 440 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 78) chain B residue 522 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI3 79) chain B residue 549 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 80) chain B residue 651 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI3 81) chain B residue 653 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 82) chain B residue 677 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 83) chain B residue 706 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 84) chain B residue 707 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 85) chain B residue 708 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 86) chain A residue 343 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 87) chain A residue 390 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 88) chain A residue 438 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 89) chain A residue 440 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 90) chain A residue 522 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI3 91) chain A residue 549 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 92) chain A residue 651 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI3 93) chain A residue 311 type catalytic sequence H description 28 source MCSA : MCSA1 94) chain A residue 312 type catalytic sequence N description 28 source MCSA : MCSA1 95) chain A residue 341 type catalytic sequence E description 28 source MCSA : MCSA1 96) chain A residue 343 type catalytic sequence D description 28 source MCSA : MCSA1 97) chain A residue 356 type catalytic sequence H description 28 source MCSA : MCSA1 98) chain A residue 390 type catalytic sequence E description 28 source MCSA : MCSA1 99) chain B residue 311 type catalytic sequence H description 28 source MCSA : MCSA2 100) chain B residue 312 type catalytic sequence N description 28 source MCSA : MCSA2 101) chain B residue 341 type catalytic sequence E description 28 source MCSA : MCSA2 102) chain B residue 343 type catalytic sequence D description 28 source MCSA : MCSA2 103) chain B residue 356 type catalytic sequence H description 28 source MCSA : MCSA2 104) chain B residue 390 type catalytic sequence E description 28 source MCSA : MCSA2 105) chain B residue 191 type CARBOHYD sequence S description O-linked (GlcNAc) serine => ECO:0000269|PubMed:24098488 source Swiss-Prot : SWS_FT_FI6 106) chain B residue 193 type CARBOHYD sequence T description O-linked (GlcNAc) threonine => ECO:0000269|PubMed:24098488 source Swiss-Prot : SWS_FT_FI7

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