eF-site ID 1djl-AB PDB Code 1djl Chain A, B click to enlarge Title THE CRYSTAL STRUCTURE OF HUMAN TRANSHYDROGENASE DOMAIN III WITH BOUND NADP Classification OXIDOREDUCTASE Compound TRANSHYDROGENASE DIII Source Homo sapiens (Human) (NNTM_HUMAN) Sequence A:  PMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQ YPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAG VPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDPN SIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPN TAMLLGDAKKTCDALQAKVRES B:  PMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQ YPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAG VPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDPN SIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPN TAMLLGDAKKTCDALQAKVRES Description Functional site 1) chain A residue 1000 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1138 source : AC1 2) chain B residue 1000 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2138 source : AC2 3) chain A residue 889 type sequence G description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 4) chain A residue 890 type sequence Y description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 5) chain A residue 891 type sequence G description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 6) chain A residue 895 type sequence A description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 7) chain A residue 922 type sequence V description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 8) chain A residue 923 type sequence A description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 9) chain A residue 924 type sequence G description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 10) chain A residue 925 type sequence R description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 11) chain A residue 926 type sequence M description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 12) chain A residue 927 type sequence P description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 13) chain A residue 964 type sequence G description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 14) chain A residue 965 type sequence A description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 15) chain A residue 966 type sequence N description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 16) chain A residue 967 type sequence D description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 17) chain A residue 968 type sequence T description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 18) chain A residue 982 type sequence A description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 19) chain A residue 983 type sequence G description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 20) chain A residue 984 type sequence M description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 21) chain A residue 999 type sequence K description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 22) chain A residue 1000 type sequence R description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 23) chain A residue 1001 type sequence S description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 24) chain A residue 1004 type sequence V description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 25) chain A residue 1005 type sequence G description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 26) chain A residue 1006 type sequence Y description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 27) chain A residue 1025 type sequence D description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 28) chain A residue 1026 type sequence A description BINDING SITE FOR RESIDUE NAP A 1136 source : AC3 29) chain B residue 889 type sequence G description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 30) chain B residue 890 type sequence Y description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 31) chain B residue 891 type sequence G description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 32) chain B residue 895 type sequence A description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 33) chain B residue 922 type sequence V description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 34) chain B residue 923 type sequence A description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 35) chain B residue 924 type sequence G description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 36) chain B residue 925 type sequence R description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 37) chain B residue 926 type sequence M description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 38) chain B residue 927 type sequence P description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 39) chain B residue 964 type sequence G description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 40) chain B residue 965 type sequence A description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 41) chain B residue 966 type sequence N description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 42) chain B residue 967 type sequence D description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 43) chain B residue 968 type sequence T description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 44) chain B residue 999 type sequence K description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 45) chain B residue 1000 type sequence R description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 46) chain B residue 1001 type sequence S description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 47) chain B residue 1004 type sequence V description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 48) chain B residue 1005 type sequence G description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 49) chain B residue 1006 type sequence Y description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 50) chain B residue 1024 type sequence G description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 51) chain B residue 1025 type sequence D description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 52) chain B residue 1026 type sequence A description BINDING SITE FOR RESIDUE NAP B 2136 source : AC4 53) chain A residue 920 type sequence H description BINDING SITE FOR RESIDUE GOL A 1137 source : AC5 54) chain A residue 922 type sequence V description BINDING SITE FOR RESIDUE GOL A 1137 source : AC5 55) chain A residue 967 type sequence D description BINDING SITE FOR RESIDUE GOL A 1137 source : AC5 56) chain A residue 981 type sequence I description BINDING SITE FOR RESIDUE GOL A 1137 source : AC5 57) chain A residue 985 type sequence P description BINDING SITE FOR RESIDUE GOL A 1137 source : AC5 58) chain A residue 986 type sequence V description BINDING SITE FOR RESIDUE GOL A 1137 source : AC5 59) chain B residue 920 type sequence H description BINDING SITE FOR RESIDUE GOL B 2137 source : AC6 60) chain B residue 967 type sequence D description BINDING SITE FOR RESIDUE GOL B 2137 source : AC6 61) chain B residue 981 type sequence I description BINDING SITE FOR RESIDUE GOL B 2137 source : AC6 62) chain B residue 984 type sequence M description BINDING SITE FOR RESIDUE GOL B 2137 source : AC6 63) chain B residue 986 type sequence V description BINDING SITE FOR RESIDUE GOL B 2137 source : AC6 64) chain A residue 890 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1PT9, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI2 65) chain B residue 1025 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1PT9, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI2 66) chain A residue 922 type BINDING sequence V description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1PT9, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI2 67) chain A residue 964 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1PT9, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI2 68) chain A residue 999 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1PT9, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI2 69) chain A residue 1025 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1PT9, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI2 70) chain B residue 890 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1PT9, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI2 71) chain B residue 922 type BINDING sequence V description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1PT9, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI2 72) chain B residue 964 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1PT9, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI2 73) chain B residue 999 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1PT9, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI2 74) chain A residue 983 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI3 75) chain B residue 983 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10673423, ECO:0000269|PubMed:15323555, ECO:0007744|PDB:1DJL, ECO:0007744|PDB:1U31 source Swiss-Prot : SWS_FT_FI3 76) chain A residue 1036 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:Q61941 source Swiss-Prot : SWS_FT_FI4 77) chain B residue 1036 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:Q61941 source Swiss-Prot : SWS_FT_FI4 78) chain A residue 890 type catalytic sequence Y description 496 source MCSA : MCSA1 79) chain A residue 925 type catalytic sequence R description 496 source MCSA : MCSA1 80) chain A residue 1006 type catalytic sequence Y description 496 source MCSA : MCSA1 81) chain B residue 890 type catalytic sequence Y description 496 source MCSA : MCSA2 82) chain B residue 925 type catalytic sequence R description 496 source MCSA : MCSA2 83) chain B residue 1006 type catalytic sequence Y description 496 source MCSA : MCSA2

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