eF-site ID 1dif-A PDB Code 1dif Chain A click to enlarge Title HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285 Classification ASPARTIC PROTEINASE Compound HIV-1 PROTEASE Source null (POL_HV1BR) Sequence A:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description (1)  HIV-1 PROTEASE, BETA-MERCAPTOETHANOL, N-{1-BENZYL-2,2-DIFLUORO-3,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE Functional site 1) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE A85 B 101 source : AC1 2) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE A85 B 101 source : AC1 3) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE A85 B 101 source : AC1 4) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE A85 B 101 source : AC1 5) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE A85 B 101 source : AC1 6) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE A85 B 101 source : AC1 7) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE A85 B 101 source : AC1 8) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE A85 B 101 source : AC1 9) chain A residue 82 type sequence V description BINDING SITE FOR RESIDUE A85 B 101 source : AC1 10) chain A residue 84 type sequence I description BINDING SITE FOR RESIDUE A85 B 101 source : AC1 11) chain A residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 22-33 type prosite sequence ALLDTGADDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL source prosite : PS00141

Display surface Download Links