eF-site ID 1dia-A PDB Code 1dia Chain A click to enlarge Title HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY249543 Classification OXIDOREDUCTASE,HYDROLASE Compound METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE Source Homo sapiens (Human) (C1TC_HUMAN) Sequence A:  APAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAIL QVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEV MKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPE KDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGV PIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAH LDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYK VVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESA KRFLE Description Functional site 1) chain A residue 148 type sequence T description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 2) chain A residue 173 type sequence R description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 3) chain A residue 174 type sequence S description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 4) chain A residue 196 type sequence H description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 5) chain A residue 197 type sequence S description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 6) chain A residue 202 type sequence L description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 7) chain A residue 216 type sequence T description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 8) chain A residue 217 type sequence G description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 9) chain A residue 218 type sequence Q description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 10) chain A residue 221 type sequence M description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 11) chain A residue 236 type sequence C description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 12) chain A residue 237 type sequence G description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 13) chain A residue 238 type sequence I description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 14) chain A residue 276 type sequence G description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 15) chain A residue 279 type sequence T description BINDING SITE FOR RESIDUE NAP A 2001 source : AC1 16) chain A residue 52 type sequence Y description BINDING SITE FOR RESIDUE L24 A 3001 source : AC3 17) chain A residue 55 type sequence V description BINDING SITE FOR RESIDUE L24 A 3001 source : AC3 18) chain A residue 56 type sequence K description BINDING SITE FOR RESIDUE L24 A 3001 source : AC3 19) chain A residue 100 type sequence Q description BINDING SITE FOR RESIDUE L24 A 3001 source : AC3 20) chain A residue 101 type sequence L description BINDING SITE FOR RESIDUE L24 A 3001 source : AC3 21) chain A residue 272 type sequence P description BINDING SITE FOR RESIDUE L24 A 3001 source : AC3 22) chain A residue 273 type sequence G description BINDING SITE FOR RESIDUE L24 A 3001 source : AC3 23) chain A residue 277 type sequence P description BINDING SITE FOR RESIDUE L24 A 3001 source : AC3 24) chain A residue 280 type sequence V description BINDING SITE FOR RESIDUE L24 A 3001 source : AC3 25) chain A residue 56 type catalytic sequence K description 389 source MCSA : MCSA1 26) chain A residue 100 type catalytic sequence Q description 389 source MCSA : MCSA1 27) chain A residue 125 type catalytic sequence D description 389 source MCSA : MCSA1 28) chain A residue 49 type catalytic sequence S description 458 source MCSA : MCSA2 29) chain A residue 56 type catalytic sequence K description 458 source MCSA : MCSA2 30) chain A residue 100 type catalytic sequence Q description 458 source MCSA : MCSA2 31) chain A residue 56 type ACT_SITE sequence K description ACT_SITE => ECO:0000269|PubMed:10828945 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 52 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10828945, ECO:0007744|PDB:1DIA, ECO:0007744|PDB:1DIB source Swiss-Prot : SWS_FT_FI2 33) chain A residue 99 type BINDING sequence V description BINDING => ECO:0000269|PubMed:10828945, ECO:0007744|PDB:1DIA, ECO:0007744|PDB:1DIB source Swiss-Prot : SWS_FT_FI2 34) chain A residue 272 type BINDING sequence P description BINDING => ECO:0000269|PubMed:10828945, ECO:0007744|PDB:1DIA, ECO:0007744|PDB:1DIB source Swiss-Prot : SWS_FT_FI2 35) chain A residue 78-103 type prosite sequence ESEVMKYITSLNEDSTVHGFLVQLPL description THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EsEVMkyItsLNeDstvhgFLVQLPL source prosite : PS00766 36) chain A residue 272-280 type prosite sequence PGGVGPMTV description THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV source prosite : PS00767 37) chain A residue 172 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:9519408, ECO:0007744|PDB:1A4I, ECO:0007744|PDB:1DIA, ECO:0007744|PDB:1DIB, ECO:0007744|PDB:1DIG source Swiss-Prot : SWS_FT_FI3 38) chain A residue 197 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:9519408, ECO:0007744|PDB:1A4I, ECO:0007744|PDB:1DIA, ECO:0007744|PDB:1DIB, ECO:0007744|PDB:1DIG source Swiss-Prot : SWS_FT_FI3

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