|
eF-site ID
|
1den_16-A |
PDB Code
|
1den |
Model
|
16 |
Chain
|
A |
|
click to enlarge
|
|
Title
|
PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS |
Classification
|
VENOM(POTASSIUM CHANNEL INHIBITOR) |
Compound
|
DENDROTOXIN I |
Source
|
Dendroaspis polylepis polylepis (Black mamba) (IVBII_DENPO) |
|
Sequence
|
A: |
QPLRKLCILHRNPGRCYQKIPAFYYNQKKKQCEGFTWSGC
GGNSNRFKTIEECRRTCIRK
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
35-53 |
type |
prosite |
sequence |
FTWSGCGGNSNRFKTIEEC
|
description |
BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FtwSGCggnsnrFktieeC
|
source |
prosite : PS00280
|
|
2)
|
chain |
A |
residue |
5 |
type |
SITE |
sequence |
K
|
description |
May be the major determinant of the binding affinity for potassium channels
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
A |
residue |
9 |
type |
SITE |
sequence |
L
|
description |
Important for binding to potassium channels
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
A |
residue |
19 |
type |
SITE |
sequence |
K
|
description |
Not important for inhibition of potassium channels
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|