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eF-site ID
|
1dan-H |
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PDB Code
|
1dan |
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Chain
|
H |
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click to enlarge
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Title
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Complex of active site inhibited human blood coagulation factor VIIA with human recombinant soluble tissue factor |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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BLOOD COAGULATION FACTOR VIIA light chain |
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Source
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(TF_HUMAN) |
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Sequence
|
H: |
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAA
HCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS
TYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERT
LAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQ
QSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMR
SEPRPGVLLRAPFP
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Description
|
(1) |
BLOOD COAGULATION FACTOR VIIA, SOLUBLE TISSUE FACTOR, D-PHE-PHE-ARG-CHLOROMETHYLKETONE (DFFRCMK) WITH CHLOROMETHYLKETONE REPLACED BY A METHYLENE GROUP, METHYLENE GROUP
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Functional site
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1)
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chain |
H |
| residue |
53-58 |
| type |
prosite |
| sequence |
VSAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
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| source |
prosite : PS00134
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2)
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chain |
H |
| residue |
189-200 |
| type |
prosite |
| sequence |
DSCKGDSGGPHA
|
| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA
|
| source |
prosite : PS00135
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3)
|
chain |
H |
| residue |
195 |
| type |
CARBOHYD |
| sequence |
S
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
H |
| residue |
189 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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5)
|
chain |
H |
| residue |
175 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725
|
| source |
Swiss-Prot : SWS_FT_FI3
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