eF-site ID 1d5z-ABC PDB Code 1d5z Chain A, B, C click to enlarge Title X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDOMIMETIC AND SEB Classification IMMUNE SYSTEM/PEPTIDE INHIBITOR Compound PROTEIN (HLA CLASS II HISTOCOMPATIBILITY ANTIGEN) Source ORGANISM_SCIENTIFIC: Staphylococcus aureus; Sequence A:  EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD CRVEHWGLDEPLLKHWEF B:  GDTRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRF DSDVGEYRAVTELGRPDAEYWNSQKDLLEQKRAAVDTYCR HNYGVGESFTVQRRVYPEVTVYPALLVCSVNGFYPGSIEV RWFRNGQEEKTGVVSTGLIQNGDWTFQTLVMLETVPRSGE VYTCQVEHPSLTSPLTVEWRA C:  SQPDPKPDELHKSSKFTGLMENMKVLYDDNHVSAINVKSI DQFLYFDLIYSIKDTKLGNYDNVRVEFKNKDLADKYKDKY VDVFGANYYYQCYFSKKKRKTCMYGGVTEHNGNQLDKYRS ITVRVFEDGKNLLSFDVQTNKKKVTAQELDYLTRHYLVKN KKLYEFNNSPYETGYIKFIENENSFWYDMMPAPGDKFDQS KYLMMYNDNKMVDSKDVKIEVYLTTK Description Functional site 1) chain A residue 9 type sequence Q description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 2) chain A residue 11 type sequence E description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 3) chain A residue 24 type sequence F description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 4) chain A residue 32 type sequence F description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 5) chain A residue 43 type sequence W description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 6) chain A residue 53 type sequence S description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 7) chain A residue 54 type sequence F description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 8) chain A residue 62 type sequence N description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 9) chain A residue 65 type sequence V description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 10) chain A residue 66 type sequence D description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 11) chain A residue 69 type sequence N description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 12) chain A residue 179 type sequence E description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 13) chain B residue 13 type sequence H description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 14) chain B residue 30 type sequence Y description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 15) chain B residue 47 type sequence Y description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 16) chain B residue 61 type sequence W description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 17) chain B residue 67 type sequence L description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 18) chain B residue 71 type sequence K description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 19) chain B residue 77 type sequence T description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 20) chain B residue 78 type sequence Y description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 21) chain B residue 81 type sequence H description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 22) chain B residue 82 type sequence N description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 23) chain B residue 85 type sequence V description BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) source : AC1 24) chain A residue 55 type SITE sequence E description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI5 25) chain A residue 62 type SITE sequence N description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI6 26) chain A residue 69 type SITE sequence N description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI7 27) chain A residue 76 type SITE sequence R description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI8 28) chain A residue 78 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 29) chain A residue 118 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 30) chain B residue 57 type BINDING sequence D description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 61 type BINDING sequence W description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 81 type BINDING sequence H description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 33) chain B residue 82 type BINDING sequence N description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 93 type BINDING sequence R description BINDING => ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 52 type BINDING sequence A description BINDING => ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 19 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 53 type SITE sequence S description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI4 38) chain C residue 115-124 type prosite sequence YGGVTEHNGN description STAPH_STREP_TOXIN_1 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. YGGVTEHngN source prosite : PS00277 39) chain C residue 152-175 type prosite sequence KKKVTAQELDYLTRHYLVKNKKLY description STAPH_STREP_TOXIN_2 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. KkkVtaqeLDyltRhyLvknkkLY source prosite : PS00278 40) chain A residue 161-167 type prosite sequence YDCRVEH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH source prosite : PS00290 41) chain B residue 171-177 type prosite sequence YTCQVEH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH source prosite : PS00290

Display surface Download Links